Shifting trends in liver-directed management of patients with colorectal liver metastasis: A population-based analysis

Skye Mayo, Jennifer E. Heckman, Andrew D. Shore, Hari Nathan, Alexander A. Parikh, John F P Bridges, Robert A. Anders, Daniel A. Anaya, Natasha S. Becker, Timothy M. Pawlik

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Background: We sought to evaluate population-based temporal trends in perioperative management, as well as short- and long-term outcomes associated with the operative management of colorectal liver metastasis (CRLM). Methods: Using Surveillance, Epidemiology and End Results-Medicare linked data, we identified 2,121 patients with operatively managed CRLM between 1991 and 2006. Clinicopathologic data, trends in operative management, and survival were examined. Results: Preoperative evaluation included computed tomography (CT; 66%), magnetic resonance imaging (MRI; 5%), and positron emission tomography (PET; 2%) with a temporal increase in the use of all 3 modalities over time (all P 3 comorbidities: 1991-1995, 3%; 2003-2006, 12%; P .05); 90-day mortality decreased from 9% to 7% over the study period (P =.007). Overall the 1-, 3-, and 5-year survivals were 74%, 42%, and 28% with no improvement over time (P =.19). On multivariate analysis, synchronous disease (hazard ratio [HR], 1.7) and use of ablation alone (HR, 1.2) were associated independently with a worse survival (both P

Original languageEnglish (US)
Pages (from-to)204-216
Number of pages13
JournalSurgery
Volume150
Issue number2
DOIs
StatePublished - Aug 2011
Externally publishedYes

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Neoplasm Metastasis
Liver
Population
Survival
Medicare
Positron-Emission Tomography
Comorbidity
Epidemiology
Multivariate Analysis
Tomography
Magnetic Resonance Imaging
Mortality

ASJC Scopus subject areas

  • Surgery

Cite this

Mayo, S., Heckman, J. E., Shore, A. D., Nathan, H., Parikh, A. A., Bridges, J. F. P., ... Pawlik, T. M. (2011). Shifting trends in liver-directed management of patients with colorectal liver metastasis: A population-based analysis. Surgery, 150(2), 204-216. https://doi.org/10.1016/j.surg.2011.06.013

Shifting trends in liver-directed management of patients with colorectal liver metastasis : A population-based analysis. / Mayo, Skye; Heckman, Jennifer E.; Shore, Andrew D.; Nathan, Hari; Parikh, Alexander A.; Bridges, John F P; Anders, Robert A.; Anaya, Daniel A.; Becker, Natasha S.; Pawlik, Timothy M.

In: Surgery, Vol. 150, No. 2, 08.2011, p. 204-216.

Research output: Contribution to journalArticle

Mayo, S, Heckman, JE, Shore, AD, Nathan, H, Parikh, AA, Bridges, JFP, Anders, RA, Anaya, DA, Becker, NS & Pawlik, TM 2011, 'Shifting trends in liver-directed management of patients with colorectal liver metastasis: A population-based analysis', Surgery, vol. 150, no. 2, pp. 204-216. https://doi.org/10.1016/j.surg.2011.06.013
Mayo, Skye ; Heckman, Jennifer E. ; Shore, Andrew D. ; Nathan, Hari ; Parikh, Alexander A. ; Bridges, John F P ; Anders, Robert A. ; Anaya, Daniel A. ; Becker, Natasha S. ; Pawlik, Timothy M. / Shifting trends in liver-directed management of patients with colorectal liver metastasis : A population-based analysis. In: Surgery. 2011 ; Vol. 150, No. 2. pp. 204-216.
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