Shear stress modulates platelet-staphylococcal interactions

Julia Ross, Konstantinos Konstantopoulos, Owen McCarty, Nehal Mohamed

Research output: Contribution to journalArticle

Abstract

Staphylococcus aureus is a common cause of hospital-acquired infections and is a leading causative organism of bloodstream infection. The binding of S. aureus to activated platelet monolayers under shear conditions was studied using a parallel-plate flow chamber and epi-fluorescent videomicroscopy. Heterotypic aggregation was also studied in suspension to stimulate interaction events in the bulk flow. Shear increased the percent of platelets bound in heteroaggregates from approximately 2% for static controls to more than 10% after 2 minutes of shear exposure.

Original languageEnglish (US)
JournalAnnals of Biomedical Engineering
Volume28
Issue numberSUPPL. 1
StatePublished - 2000
Externally publishedYes

Fingerprint

Platelets
Shear stress
Monolayers
Agglomeration

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Ross, J., Konstantopoulos, K., McCarty, O., & Mohamed, N. (2000). Shear stress modulates platelet-staphylococcal interactions. Annals of Biomedical Engineering, 28(SUPPL. 1).

Shear stress modulates platelet-staphylococcal interactions. / Ross, Julia; Konstantopoulos, Konstantinos; McCarty, Owen; Mohamed, Nehal.

In: Annals of Biomedical Engineering, Vol. 28, No. SUPPL. 1, 2000.

Research output: Contribution to journalArticle

Ross, J, Konstantopoulos, K, McCarty, O & Mohamed, N 2000, 'Shear stress modulates platelet-staphylococcal interactions', Annals of Biomedical Engineering, vol. 28, no. SUPPL. 1.
Ross, Julia ; Konstantopoulos, Konstantinos ; McCarty, Owen ; Mohamed, Nehal. / Shear stress modulates platelet-staphylococcal interactions. In: Annals of Biomedical Engineering. 2000 ; Vol. 28, No. SUPPL. 1.
@article{17bddb337de04c09a9d136d82c3311cd,
title = "Shear stress modulates platelet-staphylococcal interactions",
abstract = "Staphylococcus aureus is a common cause of hospital-acquired infections and is a leading causative organism of bloodstream infection. The binding of S. aureus to activated platelet monolayers under shear conditions was studied using a parallel-plate flow chamber and epi-fluorescent videomicroscopy. Heterotypic aggregation was also studied in suspension to stimulate interaction events in the bulk flow. Shear increased the percent of platelets bound in heteroaggregates from approximately 2{\%} for static controls to more than 10{\%} after 2 minutes of shear exposure.",
author = "Julia Ross and Konstantinos Konstantopoulos and Owen McCarty and Nehal Mohamed",
year = "2000",
language = "English (US)",
volume = "28",
journal = "Annals of Biomedical Engineering",
issn = "0090-6964",
publisher = "Springer Netherlands",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Shear stress modulates platelet-staphylococcal interactions

AU - Ross, Julia

AU - Konstantopoulos, Konstantinos

AU - McCarty, Owen

AU - Mohamed, Nehal

PY - 2000

Y1 - 2000

N2 - Staphylococcus aureus is a common cause of hospital-acquired infections and is a leading causative organism of bloodstream infection. The binding of S. aureus to activated platelet monolayers under shear conditions was studied using a parallel-plate flow chamber and epi-fluorescent videomicroscopy. Heterotypic aggregation was also studied in suspension to stimulate interaction events in the bulk flow. Shear increased the percent of platelets bound in heteroaggregates from approximately 2% for static controls to more than 10% after 2 minutes of shear exposure.

AB - Staphylococcus aureus is a common cause of hospital-acquired infections and is a leading causative organism of bloodstream infection. The binding of S. aureus to activated platelet monolayers under shear conditions was studied using a parallel-plate flow chamber and epi-fluorescent videomicroscopy. Heterotypic aggregation was also studied in suspension to stimulate interaction events in the bulk flow. Shear increased the percent of platelets bound in heteroaggregates from approximately 2% for static controls to more than 10% after 2 minutes of shear exposure.

UR - http://www.scopus.com/inward/record.url?scp=0034498754&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034498754&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0034498754

VL - 28

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

SN - 0090-6964

IS - SUPPL. 1

ER -