Shear stress modulates platelet-staphylococcal interactions

Julia Ross, Konstantinos Konstantopoulos, Owen McCarty, Nehal Mohamed

Research output: Contribution to journalConference articlepeer-review

Abstract

Staphylococcus aureus is a common cause of hospital-acquired infections and is a leading causative organism of bloodstream infection. The binding of S. aureus to activated platelet monolayers under shear conditions was studied using a parallel-plate flow chamber and epi-fluorescent videomicroscopy. Heterotypic aggregation was also studied in suspension to stimulate interaction events in the bulk flow. Shear increased the percent of platelets bound in heteroaggregates from approximately 2% for static controls to more than 10% after 2 minutes of shear exposure.

Original languageEnglish (US)
Pages (from-to)S-88
JournalAnnals of Biomedical Engineering
Volume28
Issue numberSUPPL. 1
StatePublished - Dec 1 2000
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000

ASJC Scopus subject areas

  • Biomedical Engineering

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