Shared familial transmission of autism spectrum and attention-deficit/ hyperactivity disorders

Erica D. Musser, Elizabeth Hawkey, Svetlana S. Kachan-Liu, Paul Lees, Jean Baptiste Roullet, Katrina Goddard, Robert D. Steiner, Joel T. Nigg

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Background To determine whether familial transmission is shared between autism spectrum disorders and attention-deficit/hyperactivity disorder, we assessed the prevalence, rates of comorbidity, and familial transmission of both disorders in a large population-based sample of children during a recent 7 year period. Methods Study participants included all children born to parents with the Kaiser Permanente Northwest (KPNW) Health Plan between 1 January 1998 and 31 December 2004 (n = 35,073). Children and mothers with physician-identified autism spectrum disorders (ASD) and/or attention-deficit/hyperactivity disorder (ADHD) were identified via electronic medical records maintained for all KPNW members. Results Among children aged 6-12 years, prevalence was 2.0% for ADHD and 0.8% for ASD; within those groups, 0.2% of the full sample (19% of the ASD sample and 9.6% of the ADHD sample) had co-occurring ASD and ADHD, when all children were included. When mothers had a diagnosis of ADHD, first born offspring were at 6-fold risk of ADHD alone (OR = 5.02, p <.0001) and at 2.5-fold risk of ASD alone (OR = 2.52, p <.01). Results were not accounted for by maternal age, child gestational age, child gender, and child race. Conclusions Autism spectrum disorders shares familial transmission with ADHD. ADHD and ASD have a partially overlapping diathesis.

Original languageEnglish (US)
Pages (from-to)819-827
Number of pages9
JournalJournal of Child Psychology and Psychiatry and Allied Disciplines
Volume55
Issue number7
DOIs
StatePublished - Jul 2014

Keywords

  • Attention-deficit/hyperactivity disorder
  • autism spectrum disorder
  • shared familial transmission

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology
  • Psychiatry and Mental health

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