SGK1

A rapid aldosterone-induced regulator of renal sodium reabsorption

James (Jim) McCormick, Vivek Bhalla, Alan C. Pao, David Pearce

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Recently, substantial progress has been made in understanding the mechanisms by which aldosterone rapidly stimulates sodium transport in the distal nephron and other tight epithelia. Serum- and glucocorticoid-regulated kinase 1 (SGK1) has been identified as an important mediator of this process. Its physiological relevance has been revealed through heterologous expression in cultured cells and generation of SGK1 knockout mice.

Original languageEnglish (US)
Pages (from-to)134-139
Number of pages6
JournalPhysiology
Volume20
Issue number2
StatePublished - Apr 2005
Externally publishedYes

Fingerprint

Aldosterone
Sodium
Nephrons
Knockout Mice
Cultured Cells
Epithelium
Renal Reabsorption
serum-glucocorticoid regulated kinase

ASJC Scopus subject areas

  • Physiology

Cite this

McCormick, J. J., Bhalla, V., Pao, A. C., & Pearce, D. (2005). SGK1: A rapid aldosterone-induced regulator of renal sodium reabsorption. Physiology, 20(2), 134-139.

SGK1 : A rapid aldosterone-induced regulator of renal sodium reabsorption. / McCormick, James (Jim); Bhalla, Vivek; Pao, Alan C.; Pearce, David.

In: Physiology, Vol. 20, No. 2, 04.2005, p. 134-139.

Research output: Contribution to journalArticle

McCormick, JJ, Bhalla, V, Pao, AC & Pearce, D 2005, 'SGK1: A rapid aldosterone-induced regulator of renal sodium reabsorption', Physiology, vol. 20, no. 2, pp. 134-139.
McCormick, James (Jim) ; Bhalla, Vivek ; Pao, Alan C. ; Pearce, David. / SGK1 : A rapid aldosterone-induced regulator of renal sodium reabsorption. In: Physiology. 2005 ; Vol. 20, No. 2. pp. 134-139.
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