SGK1: A rapid aldosterone-induced regulator of renal sodium reabsorption

James A. McCormick; Vivek Bhalla; Alan C. Pao; David Pearce

doi:10.1152/physiol.00053.2004

SGK1: A rapid aldosterone-induced regulator of renal sodium reabsorption

James A. McCormick, Vivek Bhalla, Alan C. Pao, David Pearce

Research output: Contribution to journal › Review article › peer-review

82 Scopus citations

Abstract

Recently, substantial progress has been made in understanding the mechanisms by which aldosterone rapidly stimulates sodium transport in the distal nephron and other tight epithelia. Serum- and glucocorticoid-regulated kinase 1 (SGK1) has been identified as an important mediator of this process. Its physiological relevance has been revealed through heterologous expression in cultured cells and generation of SGK1 knockout mice.

Original language	English (US)
Pages (from-to)	134-139
Number of pages	6
Journal	Physiology
Volume	20
Issue number	2
DOIs	https://doi.org/10.1152/physiol.00053.2004
State	Published - Apr 2005
Externally published	Yes

ASJC Scopus subject areas

Physiology

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10.1152/physiol.00053.2004

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title = "SGK1: A rapid aldosterone-induced regulator of renal sodium reabsorption",

abstract = "Recently, substantial progress has been made in understanding the mechanisms by which aldosterone rapidly stimulates sodium transport in the distal nephron and other tight epithelia. Serum- and glucocorticoid-regulated kinase 1 (SGK1) has been identified as an important mediator of this process. Its physiological relevance has been revealed through heterologous expression in cultured cells and generation of SGK1 knockout mice.",

author = "McCormick, {James A.} and Vivek Bhalla and Pao, {Alan C.} and David Pearce",

year = "2005",

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AU - McCormick, James A.

AU - Bhalla, Vivek

AU - Pao, Alan C.

AU - Pearce, David

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AB - Recently, substantial progress has been made in understanding the mechanisms by which aldosterone rapidly stimulates sodium transport in the distal nephron and other tight epithelia. Serum- and glucocorticoid-regulated kinase 1 (SGK1) has been identified as an important mediator of this process. Its physiological relevance has been revealed through heterologous expression in cultured cells and generation of SGK1 knockout mice.

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SGK1: A rapid aldosterone-induced regulator of renal sodium reabsorption

Abstract

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