Sexual differentiation of the brain

Research output: Chapter in Book/Report/Conference proceedingChapter


In male vertebrates, perinatal exposure to testosterone is both necessary and sufficient to masculinize tonic gonadotropin secretion and copulatory behavior. In contrast, females develop in the absence of high steroid exposure and express cyclic gonadotropin secretion and receptive behaviors. The cellular and molecular processes by which testosterone acts to organize sex specific brain functions are complex and can be modified by social and environmental factors. Studies of humans with clinical syndromes in which fetuses are exposed too much or too little androgen provide support that sex hormones also influence sexual differentiation of the human brain and behavior.

Original languageEnglish (US)
Title of host publicationThe Curated Reference Collection in Neuroscience and Biobehavioral Psychology
PublisherElsevier Science Ltd.
Number of pages7
ISBN (Electronic)9780128093245
StatePublished - Jan 1 2016


  • Anteroventral periventricular preoptic nucleus
  • Aromatase
  • Critical period
  • Estradiol
  • Medial preoptic area
  • Sex differences
  • Sexual differentiation
  • Sexual dimorphism
  • Sexually dimorphic nucleus
  • Spinal nucleus of the bulbocarernosus
  • Testosterone
  • Third interstitial nucleus of the anterior hypothalamus

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Sexual differentiation of the brain'. Together they form a unique fingerprint.

Cite this