Sextant localization of prostate cancer: Comparison of sextant biopsy, magnetic resonance imaging and magnetic resonance spectroscopic imaging with step section histology

A. E. Wefer, H. Hricak, D. B. Vigneron, Fergus Coakley, Y. Lu, J. Wefer, U. Mueller-Lisse, P. R. Carroll, J. Kurhanewicz

Research output: Contribution to journalArticle

309 Citations (Scopus)

Abstract

Purpose: We compared the accuracy of endorectal magnetic resonance imaging (MRI) and magnetic resonance spectroscopic imaging with that of sextant biopsy for the sextant localization of prostate cancer. Materials and Methods: Sextant biopsy, MRI, magnetic resonance spectroscopic imaging and radical prostatectomy with step section histology were done in 47 patients with prostate cancer. For each sextant we categorized biopsy and imaging results as positive or negative for cancer. Step section histology was used as the standard of reference. Results: For sextant localization of prostate cancer MRI and magnetic resonance spectroscopic imaging were more sensitive but less specific than biopsy (67% and 76% versus 50%, and 69% and 68% versus 82%, respectively). The sensitivity of sextant biopsy was significantly less in the prostate apex than in the mid prostate or prostate base (38% versus 52% and 62%, respectively). MRI and magnetic resonance spectroscopic imaging had similar efficacy throughout the prostate compared with biopsy only as well as better sensitivity and specificity in the prostate apex (60% and 75%, and 86% and 68%, respectively). A positive biopsy or imaging result had 94% sensitivity for cancer and concordant positivity by all 3 tests was highly specific at 98%. Conclusions: Overall MRI and magnetic resonance spectroscopic imaging have accuracy similar to biopsy for intraprostatic localization of cancer and they are more accurate than biopsy in the prostate apex. These 2 imaging modalities may supplement biopsy results by increasing physician confidence when evaluating intraprostatic tumor location, which may be important for planning disease targeted therapy.

Original languageEnglish (US)
Pages (from-to)400-404
Number of pages5
JournalJournal of Urology
Volume164
Issue number2
StatePublished - Aug 2000
Externally publishedYes

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Prostatic Neoplasms
Histology
Magnetic Resonance Imaging
Biopsy
Prostate
Neoplasms
Prostatectomy
Physicians
Sensitivity and Specificity

Keywords

  • Biopsy
  • Magnetic resonance imaging
  • Needle
  • Prostate
  • Prostatic neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Sextant localization of prostate cancer : Comparison of sextant biopsy, magnetic resonance imaging and magnetic resonance spectroscopic imaging with step section histology. / Wefer, A. E.; Hricak, H.; Vigneron, D. B.; Coakley, Fergus; Lu, Y.; Wefer, J.; Mueller-Lisse, U.; Carroll, P. R.; Kurhanewicz, J.

In: Journal of Urology, Vol. 164, No. 2, 08.2000, p. 400-404.

Research output: Contribution to journalArticle

Wefer, AE, Hricak, H, Vigneron, DB, Coakley, F, Lu, Y, Wefer, J, Mueller-Lisse, U, Carroll, PR & Kurhanewicz, J 2000, 'Sextant localization of prostate cancer: Comparison of sextant biopsy, magnetic resonance imaging and magnetic resonance spectroscopic imaging with step section histology', Journal of Urology, vol. 164, no. 2, pp. 400-404.
Wefer, A. E. ; Hricak, H. ; Vigneron, D. B. ; Coakley, Fergus ; Lu, Y. ; Wefer, J. ; Mueller-Lisse, U. ; Carroll, P. R. ; Kurhanewicz, J. / Sextant localization of prostate cancer : Comparison of sextant biopsy, magnetic resonance imaging and magnetic resonance spectroscopic imaging with step section histology. In: Journal of Urology. 2000 ; Vol. 164, No. 2. pp. 400-404.
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abstract = "Purpose: We compared the accuracy of endorectal magnetic resonance imaging (MRI) and magnetic resonance spectroscopic imaging with that of sextant biopsy for the sextant localization of prostate cancer. Materials and Methods: Sextant biopsy, MRI, magnetic resonance spectroscopic imaging and radical prostatectomy with step section histology were done in 47 patients with prostate cancer. For each sextant we categorized biopsy and imaging results as positive or negative for cancer. Step section histology was used as the standard of reference. Results: For sextant localization of prostate cancer MRI and magnetic resonance spectroscopic imaging were more sensitive but less specific than biopsy (67{\%} and 76{\%} versus 50{\%}, and 69{\%} and 68{\%} versus 82{\%}, respectively). The sensitivity of sextant biopsy was significantly less in the prostate apex than in the mid prostate or prostate base (38{\%} versus 52{\%} and 62{\%}, respectively). MRI and magnetic resonance spectroscopic imaging had similar efficacy throughout the prostate compared with biopsy only as well as better sensitivity and specificity in the prostate apex (60{\%} and 75{\%}, and 86{\%} and 68{\%}, respectively). A positive biopsy or imaging result had 94{\%} sensitivity for cancer and concordant positivity by all 3 tests was highly specific at 98{\%}. Conclusions: Overall MRI and magnetic resonance spectroscopic imaging have accuracy similar to biopsy for intraprostatic localization of cancer and they are more accurate than biopsy in the prostate apex. These 2 imaging modalities may supplement biopsy results by increasing physician confidence when evaluating intraprostatic tumor location, which may be important for planning disease targeted therapy.",
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