Sex, sex steroids, and brain injury

Paco S. Herson, Ines Koerner, Patricia D. Hurn

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Biologic sex and sex steroids are important factors in clinical and experimental stroke and traumatic brain injury (TBI). Laboratory data strongly show that progesterone treatment after TBI reduces edema, improves outcomes, and restores blood-brain barrier function. Clinical studies to date agree with these data, and there are ongoing human trials for progesterone treatment after TBI. Estrogen has accumulated an impressive reputation as a neuroprotectant when evaluated at physiologically relevant doses in laboratory studies of stroke, but translation to patients remains to be shown. The role of androgens in male stroke or TBI is understudied and important to pursue given the epidemiology of stroke and trauma in men. To date, male sex steroids remain largely evaluated at the bench rather than the bedside. This review evaluates key evidence and highlights the importance of the platform on which brain injury occurs (i.e., genetic sex and hormonal modulators).

Original languageEnglish (US)
Pages (from-to)229-239
Number of pages11
JournalSeminars in Reproductive Medicine
Volume27
Issue number3
DOIs
StatePublished - May 2009

Fingerprint

Brain Injuries
Stroke
Steroids
Progesterone
Neuroprotective Agents
Blood-Brain Barrier
Androgens
Edema
Estrogens
Epidemiology
Traumatic Brain Injury
Wounds and Injuries
Therapeutics

Keywords

  • Allopregnanolone
  • Androgens
  • Brain ischemia
  • Estradiol
  • Neurosteroids
  • Progesterone
  • Stroke

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Sex, sex steroids, and brain injury. / Herson, Paco S.; Koerner, Ines; Hurn, Patricia D.

In: Seminars in Reproductive Medicine, Vol. 27, No. 3, 05.2009, p. 229-239.

Research output: Contribution to journalArticle

Herson, Paco S. ; Koerner, Ines ; Hurn, Patricia D. / Sex, sex steroids, and brain injury. In: Seminars in Reproductive Medicine. 2009 ; Vol. 27, No. 3. pp. 229-239.
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