Sex-related differences in the susceptibility of rats to gentamicin nephrotoxicity

W. M. Bennett, Richard Parker, W. C. Elliott, D. N. Gilbert, Donald Houghton

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Age-matched male and female Fischer 344 rats were treated with gentamicin, 40 mg/kg of animal body weight per day, for three to 21 days. Renal dysfunction was less severe in females as measured by concentrations of blood urea nitrogen and creatinine and by cortical slice uptake of p-aminohippuric acid and N1-methylnicotinamide chloride. Also, cortical concentrations of gentamicin in females were lower than in males. Neither exogenous testosterone administered to adult females nor castration of prepubertal males changed the pattern of dysfunction. These results show that sex affects susceptibility to aminoglycoside nephrotoxicity by mechanisms that are undefined but that are apparently unrelated to testosterone. The variability of sex needs to be considered in interpreting the results of studies of experimental aminoglycoside nephrotoxicity.

Original languageEnglish (US)
Pages (from-to)370-373
Number of pages4
JournalJournal of Infectious Diseases
Volume145
Issue number3
StatePublished - 1982

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Gentamicins
Sex Characteristics
Aminoglycosides
Testosterone
p-Aminohippuric Acid
Blood Urea Nitrogen
Inbred F344 Rats
Ovariectomy
Chlorides
Creatinine
Body Weight
Kidney

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Bennett, W. M., Parker, R., Elliott, W. C., Gilbert, D. N., & Houghton, D. (1982). Sex-related differences in the susceptibility of rats to gentamicin nephrotoxicity. Journal of Infectious Diseases, 145(3), 370-373.

Sex-related differences in the susceptibility of rats to gentamicin nephrotoxicity. / Bennett, W. M.; Parker, Richard; Elliott, W. C.; Gilbert, D. N.; Houghton, Donald.

In: Journal of Infectious Diseases, Vol. 145, No. 3, 1982, p. 370-373.

Research output: Contribution to journalArticle

Bennett, WM, Parker, R, Elliott, WC, Gilbert, DN & Houghton, D 1982, 'Sex-related differences in the susceptibility of rats to gentamicin nephrotoxicity', Journal of Infectious Diseases, vol. 145, no. 3, pp. 370-373.
Bennett, W. M. ; Parker, Richard ; Elliott, W. C. ; Gilbert, D. N. ; Houghton, Donald. / Sex-related differences in the susceptibility of rats to gentamicin nephrotoxicity. In: Journal of Infectious Diseases. 1982 ; Vol. 145, No. 3. pp. 370-373.
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