TY - JOUR
T1 - Sex hormones partially explain the sex-dependent effect of lifetime alcohol use on adolescent white matter microstructure
AU - Jones, Scott A.
AU - Kliamovich, Dakota
AU - Nagel, Bonnie J.
N1 - Funding Information:
Past and present members of the Developmental Brain Imaging Lab are thanked for assisting in participant recruitment and data collection. This work was supported by the National Institute on Alcohol Abuse and Alcoholism [Nagel R01 AA017664; Kliamovich T32 AA07468], as well as the National Institute of Health (S10OD021701 and S10OD018224) for the 3T Siemens Prisma MRI instrument and High-Performance Computing Cluster, housed in OHSU's Advanced Imaging Research Center, and supported by the Oregon Opportunity Partnership for advancing biomedical research.
Funding Information:
Past and present members of the Developmental Brain Imaging Lab are thanked for assisting in participant recruitment and data collection. This work was supported by the National Institute on Alcohol Abuse and Alcoholism [Nagel R01 AA017664 ; Kliamovich T32 AA07468 ], as well as the National Institute of Health ( S10OD021701 and S10OD018224 ) for the 3T Siemens Prisma MRI instrument and High-Performance Computing Cluster, housed in OHSU's Advanced Imaging Research Center, and supported by the Oregon Opportunity Partnership for advancing biomedical research.
Publisher Copyright:
© 2020
PY - 2021/1/30
Y1 - 2021/1/30
N2 - Previous studies demonstrate profound sex-specific patterns of white matter microstructural neurodevelopment (i.e. fractional anisotropy; FA, and mean diffusivity; MD) during adolescence. While alcohol use has been associated with alterations in FA and MD, no studies have addressed the potential for sex-specific, alcohol-dose-dependent effects, during development. This prospective longitudinal study (2–4 visits, 310 total scans) used voxel-wise multilevel modeling, in 132 (68 female) adolescents (ages 12–21), to assess the sex-specific effects of lifetime alcohol use on FA and MD, during development. Follow-up analyses tested the role of sex hormones, testosterone and estradiol, in explaining the effects of alcohol use on FA and MD. In the splenium of the corpus callosum and posterior thalamic radiation, male adolescents demonstrated lower FA and greater MD as a function of more lifetime alcohol use, while female adolescents demonstrated the opposite. Further, significant associations between sex hormones and FA/MD partially explained the effect of alcohol use on FA and MD in male adolescents. These results provide evidence for sex-specific and dose-related effects of alcohol use on white matter microstructure, which are partially explained by sex hormones, and highlight the importance of studying sex and hormones when investigating the effects of alcohol use on the adolescent brain.
AB - Previous studies demonstrate profound sex-specific patterns of white matter microstructural neurodevelopment (i.e. fractional anisotropy; FA, and mean diffusivity; MD) during adolescence. While alcohol use has been associated with alterations in FA and MD, no studies have addressed the potential for sex-specific, alcohol-dose-dependent effects, during development. This prospective longitudinal study (2–4 visits, 310 total scans) used voxel-wise multilevel modeling, in 132 (68 female) adolescents (ages 12–21), to assess the sex-specific effects of lifetime alcohol use on FA and MD, during development. Follow-up analyses tested the role of sex hormones, testosterone and estradiol, in explaining the effects of alcohol use on FA and MD. In the splenium of the corpus callosum and posterior thalamic radiation, male adolescents demonstrated lower FA and greater MD as a function of more lifetime alcohol use, while female adolescents demonstrated the opposite. Further, significant associations between sex hormones and FA/MD partially explained the effect of alcohol use on FA and MD in male adolescents. These results provide evidence for sex-specific and dose-related effects of alcohol use on white matter microstructure, which are partially explained by sex hormones, and highlight the importance of studying sex and hormones when investigating the effects of alcohol use on the adolescent brain.
KW - Corpus callosum
KW - Diffusion weighted imaging
KW - Estradiol
KW - Sex differences
KW - Testosterone
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U2 - 10.1016/j.pscychresns.2020.111230
DO - 10.1016/j.pscychresns.2020.111230
M3 - Article
C2 - 33271433
AN - SCOPUS:85096853044
SN - 0925-4927
VL - 307
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
M1 - 111230
ER -