Sex hormone levels in patients with sudden cardiac arrest

Kumar Narayanan, Rasmus Havmoeller, Kyndaron Reinier, Katherine Jerger, Carmen Teodorescu, Audrey Uy-Evanado, Jo Navarro, Adriana Huertas-Vazquez, Karen Gunson, Jonathan Jui, Sumeet S. Chugh

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Methods In the ongoing Oregon Sudden Unexpected Death Study (catchment population approximately 1 million), cases of SCA were compared with matched controls. Testosterone and estradiol levels were measured from blood samples drawn at the time of the SCA event in cases and during a routine visit in controls.

Results Among cases (n = 149, age 64.1 ± 11.7 years, 73.2% male), compared to controls (n = 149, 64.2 ± 11.6 years, 72.5% male), median testosterone levels were significantly lower in males (4.4 vs 5.4 ng/mL, P =.01). Median estradiol levels were higher in male (68 vs 52 pg/mL, P

Conclusion We observed significant differences in sex hormone levels in patients who suffered SCA, with potential mechanistic implications. The role of sex hormones in the genesis of fatal ventricular arrhythmias warrants further exploration.

Background Sex hormones are known to have significant effects on the pathophysiology of cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)2267-2272
Number of pages6
JournalHeart Rhythm
Volume11
Issue number12
DOIs
StatePublished - Dec 1 2014

Fingerprint

Sudden Cardiac Death
Gonadal Steroid Hormones
Testosterone
Estradiol
Sudden Death
Cardiac Arrhythmias
Cardiovascular Diseases
Population

Keywords

  • Estradiol
  • Sudden cardiac arrest
  • Testosterone

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Narayanan, K., Havmoeller, R., Reinier, K., Jerger, K., Teodorescu, C., Uy-Evanado, A., ... Chugh, S. S. (2014). Sex hormone levels in patients with sudden cardiac arrest. Heart Rhythm, 11(12), 2267-2272. https://doi.org/10.1016/j.hrthm.2014.08.031

Sex hormone levels in patients with sudden cardiac arrest. / Narayanan, Kumar; Havmoeller, Rasmus; Reinier, Kyndaron; Jerger, Katherine; Teodorescu, Carmen; Uy-Evanado, Audrey; Navarro, Jo; Huertas-Vazquez, Adriana; Gunson, Karen; Jui, Jonathan; Chugh, Sumeet S.

In: Heart Rhythm, Vol. 11, No. 12, 01.12.2014, p. 2267-2272.

Research output: Contribution to journalArticle

Narayanan, K, Havmoeller, R, Reinier, K, Jerger, K, Teodorescu, C, Uy-Evanado, A, Navarro, J, Huertas-Vazquez, A, Gunson, K, Jui, J & Chugh, SS 2014, 'Sex hormone levels in patients with sudden cardiac arrest', Heart Rhythm, vol. 11, no. 12, pp. 2267-2272. https://doi.org/10.1016/j.hrthm.2014.08.031
Narayanan K, Havmoeller R, Reinier K, Jerger K, Teodorescu C, Uy-Evanado A et al. Sex hormone levels in patients with sudden cardiac arrest. Heart Rhythm. 2014 Dec 1;11(12):2267-2272. https://doi.org/10.1016/j.hrthm.2014.08.031
Narayanan, Kumar ; Havmoeller, Rasmus ; Reinier, Kyndaron ; Jerger, Katherine ; Teodorescu, Carmen ; Uy-Evanado, Audrey ; Navarro, Jo ; Huertas-Vazquez, Adriana ; Gunson, Karen ; Jui, Jonathan ; Chugh, Sumeet S. / Sex hormone levels in patients with sudden cardiac arrest. In: Heart Rhythm. 2014 ; Vol. 11, No. 12. pp. 2267-2272.
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