Sex differences in regulatory cells in experimental stroke

Hilary A. Seifert, Gil Benedek, Jian Liang, Ha Nguyen, Gail Kent, Arthur A. Vandenbark, Julie A. Saugstad, Halina Offner

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Stroke is the leading cause of disability in the United States. Sex differences, including smaller infarcts in females and greater involvement of immune-mediated inflammation in males may affect the efficacy of immune-modulating interventions. To address these differences, we sought to identify distinct stroke-modifying mechanisms in female vs. male mice. The current study demonstrated smaller infarcts and increased levels of regulatory CD19+CD5+CD1dhi B10 cells as well as anti-inflammatory CD11b+CD206+ microglia/macrophages in the ipsilateral vs. contralateral hemisphere of female but not male mice undergoing 60 min middle cerebral artery occlusion followed by 96 h of reperfusion. Moreover, female mice with MCAO had increased total spleen cell numbers but lower B10 levels in spleens. These results elucidate differing sex-dependent regulatory mechanisms that account for diminished stroke severity in females and underscore the need to test immune-modulating therapies for stroke in both males and females.

Original languageEnglish (US)
Pages (from-to)49-54
Number of pages6
JournalCellular Immunology
Volume318
DOIs
StatePublished - Aug 2017

Keywords

  • Anti-inflammatory macrophages
  • Lymphocyte
  • Middle cerebral artery occlusion
  • Regulatory B cells
  • Regulatory T cells
  • Sex-specific

ASJC Scopus subject areas

  • Immunology

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