Sex differences in prefrontal volume with aging and Alzheimer's disease

D. H. Salat, P. A. Stangl, J. A. Kaye, J. S. Janowsky

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

We used volumetric magnetic resonance imaging to examine sex differences in prefrontal tissue volumes of healthy aged and patients with Alzheimer's disease (AD). Healthy subjects had greater total prefrontal volume than AD, and men had greater total prefrontal volume than women (ps ≤ 0.02). This was true for both gray and white matter volumes. There were no interactions between group and sex for total prefrontal volume. An exploratory analysis of each group suggested that sex differences in both gray and white matter in healthy aging are not sustained in AD. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)591-596
Number of pages6
JournalNeurobiology of Aging
Volume20
Issue number6
DOIs
StatePublished - Nov 1 1999

Keywords

  • Aged
  • Aging
  • Alzheimer's disease
  • Frontal lobe
  • Gray matter
  • Human
  • Magnetic resonance imaging
  • Prefrontal
  • Sex characteristics

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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