Sex differences in androgen regulation of metabolism in nonhuman primates

Cadence True, David H. Abbott, Charles Roberts, Oleg Varlamov

    Research output: Chapter in Book/Report/Conference proceedingChapter

    4 Scopus citations

    Abstract

    The in-depth characterization of sex differences relevant to human physiology requires the judicious use of a variety of animal models and human clinical data. Nonhuman primates (NHPs) represent an important experimental system that bridges rodent studies and clinical investigations. NHP studies have been especially useful in understanding the role of sex hormones in development and metabolism and also allow the elucidation of the effects of pertinent dietary influences on physiology pertinent to disease states such as obesity and diabetes. This chapter summarizes the current state of our understanding of androgen effects on male and female NHP metabolism relevant to hypogonadism in human males and polycystic ovary syndrome in human females. This review will also focus on the interaction between altered androgen levels and dietary restriction and excess, in particular the Westernstyle diet that underlies significant human pathophysiology.

    Original languageEnglish (US)
    Title of host publicationAdvances in Experimental Medicine and Biology
    PublisherSpringer New York LLC
    Pages559-574
    Number of pages16
    Volume1043
    DOIs
    StatePublished - Jan 1 2017

    Publication series

    NameAdvances in Experimental Medicine and Biology
    Volume1043
    ISSN (Print)0065-2598
    ISSN (Electronic)2214-8019

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    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    True, C., Abbott, D. H., Roberts, C., & Varlamov, O. (2017). Sex differences in androgen regulation of metabolism in nonhuman primates. In Advances in Experimental Medicine and Biology (Vol. 1043, pp. 559-574). (Advances in Experimental Medicine and Biology; Vol. 1043). Springer New York LLC. https://doi.org/10.1007/978-3-319-70178-3_24