Sex biology contributions to vulnerability to Alzheimer's disease: A think tank convened by the Women's Alzheimer's Research Initiative

Heather M. Snyder; Sanjay Asthana; Lisa Bain; Roberta Brinton; Suzanne Craft; Dena B. Dubal; Mark A. Espeland; Margaret Gatz; Michelle M. Mielke; Jacob Raber; Peter R. Rapp; Kristine Yaffe; Maria C. Carrillo

doi:10.1016/j.jalz.2016.08.004

Sex biology contributions to vulnerability to Alzheimer's disease: A think tank convened by the Women's Alzheimer's Research Initiative

Heather M. Snyder, Sanjay Asthana, Lisa Bain, Roberta Brinton, Suzanne Craft, Dena B. Dubal, Mark A. Espeland, Margaret Gatz, Michelle M. Mielke, Jacob Raber, Peter R. Rapp, Kristine Yaffe, Maria C. Carrillo

Behavioral Neuroscience

Research output: Contribution to journal › Review article › peer-review

118 Scopus citations

Abstract

More than 5 million Americans are living with Alzheimer's disease (AD) today, and nearly two-thirds of Americans with AD are women. This sex difference may be due to the higher longevity women generally experience; however, increasing evidence suggests that longevity alone is not a sufficient explanation and there may be other factors at play. The Alzheimer's Association convened an expert think tank to focus on the state of the science and level of evidence around gender and biological sex differences for AD, including the knowledge gaps and areas of science that need to be more fully addressed. This article summarizes the think tank discussion, moving forward a research agenda and funding program to better understand the biological underpinnings of sex- and gender-related disparities of risk for AD.

Original language	English (US)
Pages (from-to)	1186-1196
Number of pages	11
Journal	Alzheimer's and Dementia
Volume	12
Issue number	11
DOIs	https://doi.org/10.1016/j.jalz.2016.08.004
State	Published - Nov 1 2016

Keywords

APOE
Alzheimer's disease
Estrogen
Hormones
Neurodegeneration
Risk factors
Sex biology
Women

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health
Cellular and Molecular Neuroscience

Access to Document

10.1016/j.jalz.2016.08.004

Cite this

Snyder, H. M., Asthana, S., Bain, L., Brinton, R., Craft, S., Dubal, D. B., Espeland, M. A., Gatz, M., Mielke, M. M., Raber, J., Rapp, P. R., Yaffe, K., & Carrillo, M. C. (2016). Sex biology contributions to vulnerability to Alzheimer's disease: A think tank convened by the Women's Alzheimer's Research Initiative. Alzheimer's and Dementia, 12(11), 1186-1196. https://doi.org/10.1016/j.jalz.2016.08.004

Snyder, HM, Asthana, S, Bain, L, Brinton, R, Craft, S, Dubal, DB, Espeland, MA, Gatz, M, Mielke, MM, Raber, J, Rapp, PR, Yaffe, K & Carrillo, MC 2016, 'Sex biology contributions to vulnerability to Alzheimer's disease: A think tank convened by the Women's Alzheimer's Research Initiative', Alzheimer's and Dementia, vol. 12, no. 11, pp. 1186-1196. https://doi.org/10.1016/j.jalz.2016.08.004

@article{9d4e7c0107e6423faabb2591d7affc3b,

title = "Sex biology contributions to vulnerability to Alzheimer's disease: A think tank convened by the Women's Alzheimer's Research Initiative",

abstract = "More than 5 million Americans are living with Alzheimer's disease (AD) today, and nearly two-thirds of Americans with AD are women. This sex difference may be due to the higher longevity women generally experience; however, increasing evidence suggests that longevity alone is not a sufficient explanation and there may be other factors at play. The Alzheimer's Association convened an expert think tank to focus on the state of the science and level of evidence around gender and biological sex differences for AD, including the knowledge gaps and areas of science that need to be more fully addressed. This article summarizes the think tank discussion, moving forward a research agenda and funding program to better understand the biological underpinnings of sex- and gender-related disparities of risk for AD.",

keywords = "APOE, Alzheimer's disease, Estrogen, Hormones, Neurodegeneration, Risk factors, Sex biology, Women",

author = "Snyder, {Heather M.} and Sanjay Asthana and Lisa Bain and Roberta Brinton and Suzanne Craft and Dubal, {Dena B.} and Espeland, {Mark A.} and Margaret Gatz and Mielke, {Michelle M.} and Jacob Raber and Rapp, {Peter R.} and Kristine Yaffe and Carrillo, {Maria C.}",

note = "Publisher Copyright: {\textcopyright} 2016 The Alzheimer's Association",

year = "2016",

month = nov,

day = "1",

doi = "10.1016/j.jalz.2016.08.004",

language = "English (US)",

volume = "12",

pages = "1186--1196",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "Elsevier Inc.",

number = "11",

}

TY - JOUR

T1 - Sex biology contributions to vulnerability to Alzheimer's disease

T2 - A think tank convened by the Women's Alzheimer's Research Initiative

AU - Snyder, Heather M.

AU - Asthana, Sanjay

AU - Bain, Lisa

AU - Brinton, Roberta

AU - Craft, Suzanne

AU - Dubal, Dena B.

AU - Espeland, Mark A.

AU - Gatz, Margaret

AU - Mielke, Michelle M.

AU - Raber, Jacob

AU - Rapp, Peter R.

AU - Yaffe, Kristine

AU - Carrillo, Maria C.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - More than 5 million Americans are living with Alzheimer's disease (AD) today, and nearly two-thirds of Americans with AD are women. This sex difference may be due to the higher longevity women generally experience; however, increasing evidence suggests that longevity alone is not a sufficient explanation and there may be other factors at play. The Alzheimer's Association convened an expert think tank to focus on the state of the science and level of evidence around gender and biological sex differences for AD, including the knowledge gaps and areas of science that need to be more fully addressed. This article summarizes the think tank discussion, moving forward a research agenda and funding program to better understand the biological underpinnings of sex- and gender-related disparities of risk for AD.

AB - More than 5 million Americans are living with Alzheimer's disease (AD) today, and nearly two-thirds of Americans with AD are women. This sex difference may be due to the higher longevity women generally experience; however, increasing evidence suggests that longevity alone is not a sufficient explanation and there may be other factors at play. The Alzheimer's Association convened an expert think tank to focus on the state of the science and level of evidence around gender and biological sex differences for AD, including the knowledge gaps and areas of science that need to be more fully addressed. This article summarizes the think tank discussion, moving forward a research agenda and funding program to better understand the biological underpinnings of sex- and gender-related disparities of risk for AD.

KW - APOE

KW - Alzheimer's disease

KW - Estrogen

KW - Hormones

KW - Neurodegeneration

KW - Risk factors

KW - Sex biology

KW - Women

UR - http://www.scopus.com/inward/record.url?scp=84994462651&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994462651&partnerID=8YFLogxK

U2 - 10.1016/j.jalz.2016.08.004

DO - 10.1016/j.jalz.2016.08.004

M3 - Review article

C2 - 27692800

AN - SCOPUS:84994462651

SN - 1552-5260

VL - 12

SP - 1186

EP - 1196

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 11

ER -

Sex biology contributions to vulnerability to Alzheimer's disease: A think tank convened by the Women's Alzheimer's Research Initiative

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this