Sex and genotype determine the selective activation of neurochemically-distinct mechanisms of swim stress-induced analgesia

Jeffrey S. Mogil, John Belknap

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

A growing literature documents the important influence of organismic factors such as sex and genotype on pain sensitivity and pain modulation. We recently determined that 3-min forced swims in 15°C water produce non-opioid (i.e., naloxone-insensitive) analgesia in outbred Swiss-Webster mice of both sexes; this form of stress-induced analgesia (SIA) is significantly attenuated by the N-methyl-D-aspartate (NMDA) antagonist, dizocilpine (MK-801) in males, but not females. A pilot study designed to confirm the non-opioid and (in male mice) NMDAergic nature of 15°C swim SIA in the C57BL/6J and DBA/2J inbred strains used widely in gene mapping was conducted, using the hot-plate (54°C) assay of nociception. In female mice of both strains, 15°C swim SIA was insensitive to antagonism by either naloxone (10 mg/kg, IP) or dizocilpine (0.1 mg/kg, IP). In male C57BL/6J mice, the observed SIA was naloxone-insensitive, but was attenuated by dizocilpine. This pattern of results is virtually identical to that obtained using Swiss-Webster mice in this and previous studies. However, male DBA/2J mice displayed SIA that was significantly attenuated by naloxone, but insensitive to dizocilpine antagonism. These findings support the hypothesis that genetic factors and sex, in addition to stressor parameters, can determine the selective recruitment of alternative central mechanisms of pain inhibition.

Original languageEnglish (US)
Pages (from-to)61-66
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume56
Issue number1
DOIs
StatePublished - Jan 1996

Fingerprint

Dizocilpine Maleate
Analgesia
Naloxone
Chemical activation
Genotype
Pain
Sex Factors
N-Methylaspartate
Inbred DBA Mouse
Nociception
Chromosome Mapping
Assays
Inbred C57BL Mouse
Genes
Modulation
Water

Keywords

  • C57BL/6 mice
  • DBA/2 mice
  • genetics
  • non-opioid
  • sex differences

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Sex and genotype determine the selective activation of neurochemically-distinct mechanisms of swim stress-induced analgesia. / Mogil, Jeffrey S.; Belknap, John.

In: Pharmacology Biochemistry and Behavior, Vol. 56, No. 1, 01.1996, p. 61-66.

Research output: Contribution to journalArticle

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