Severity of neuropsychological impairment in cocaine and alcohol addiction: Association with metabolism in the prefrontal cortex

Rita Z. Goldstein, Andreana C. Leskovjan, Anne L. Hoff, Robert Hitzemann, Francine Bashan, Sahib Singh Khalsa, Gene Jack Wang, Joanna S. Fowler, Nora D. Volkow

Research output: Contribution to journalArticle

253 Citations (Scopus)

Abstract

We used exploratory and confirmatory statistical approaches to study the severity of neuropsychological (NP) impairment in 42 crack/cocaine addicted subjects and in 112 comparison subjects (40 alcoholics and 72 controls). Twenty neuropsychological test indices most reliably defining predetermined cognitive domains were submitted to exploratory factor analysis. A four-dimensional model of neurocognitive function was derived: Verbal Knowledge, Visual Memory, Verbal Memory, and Attention/Executive functioning accounted for 63% of the variance. We then examined this model's association with resting glucose metabolism in the brain reward circuit measured with 2-deoxy-2[18F]fluoro-D-glucose positron emission tomography. Results revealed that (1) cocaine addicted individuals had a generalized mild level of neurocognitive impairment (

Original languageEnglish (US)
Pages (from-to)1447-1458
Number of pages12
JournalNeuropsychologia
Volume42
Issue number11
DOIs
StatePublished - 2004

Fingerprint

Cocaine-Related Disorders
Prefrontal Cortex
Alcoholism
Crack Cocaine
Neuropsychological Tests
Fluorodeoxyglucose F18
Alcoholics
Reward
Cocaine
Positron-Emission Tomography
Statistical Factor Analysis
Glucose
Brain

Keywords

  • Cognitive functioning
  • Drug abuse
  • Functional neuroimaging
  • PET FDG

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Severity of neuropsychological impairment in cocaine and alcohol addiction : Association with metabolism in the prefrontal cortex. / Goldstein, Rita Z.; Leskovjan, Andreana C.; Hoff, Anne L.; Hitzemann, Robert; Bashan, Francine; Khalsa, Sahib Singh; Wang, Gene Jack; Fowler, Joanna S.; Volkow, Nora D.

In: Neuropsychologia, Vol. 42, No. 11, 2004, p. 1447-1458.

Research output: Contribution to journalArticle

Goldstein, Rita Z. ; Leskovjan, Andreana C. ; Hoff, Anne L. ; Hitzemann, Robert ; Bashan, Francine ; Khalsa, Sahib Singh ; Wang, Gene Jack ; Fowler, Joanna S. ; Volkow, Nora D. / Severity of neuropsychological impairment in cocaine and alcohol addiction : Association with metabolism in the prefrontal cortex. In: Neuropsychologia. 2004 ; Vol. 42, No. 11. pp. 1447-1458.
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