Severity of demyelination in vivo correlates with serum myelination inhibition activity in guinea pigs having a new form of experimental allergic encephalomyelitis

Dennis N. Bourdette, Bernard F. Driscoll, Fredrick J. Seil, Marian W. Kies, Ellsworth C. Alvord

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Guinea pigs received a suboptimal transfer of lymphocytes sensitized to myelin basic protein (BP) and were then immunized with guinea pig BP, BP plus chicken brain or chicken myelin, or chicken brain alone. Sera from these animals were tested for the presence of myelinotoxic antibodies, as detected by the myelination inhibition assay. Myelination inhibition activity correlated with the histologic severity of demyelination.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalNeurochemical Pathology
Volume4
Issue number1
DOIs
StatePublished - Feb 1 1986

Keywords

  • Experimental allergic encephalomyelitis
  • antibody-mediated demyelination
  • demyelinating diseases
  • mechanisms of demyelination
  • myelination inhibition in vitro
  • myelinotoxic antibodies

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Neurology

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