Severity of demyelination in vivo correlates with serum myelination inhibition activity in guinea pigs having a new form of experimental allergic encephalomyelitis

Dennis Bourdette, Bernard F. Driscoll, Fredrick J. Seil, Marian W. Kies, Ellsworth C. Alvord

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Guinea pigs received a suboptimal transfer of lymphocytes sensitized to myelin basic protein (BP) and were then immunized with guinea pig BP, BP plus chicken brain or chicken myelin, or chicken brain alone. Sera from these animals were tested for the presence of myelinotoxic antibodies, as detected by the myelination inhibition assay. Myelination inhibition activity correlated with the histologic severity of demyelination.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalNeurochemical Pathology
Volume4
Issue number1
DOIs
StatePublished - Feb 1986

Fingerprint

Autoimmune Experimental Encephalomyelitis
Demyelinating Diseases
Chickens
Guinea Pigs
Serum
Myelin Basic Protein
Brain
Myelin Sheath
Proteins
Lymphocytes
Antibodies

Keywords

  • antibody-mediated demyelination
  • demyelinating diseases
  • Experimental allergic encephalomyelitis
  • mechanisms of demyelination
  • myelination inhibition in vitro
  • myelinotoxic antibodies

ASJC Scopus subject areas

  • Clinical Neurology
  • Molecular Biology

Cite this

Severity of demyelination in vivo correlates with serum myelination inhibition activity in guinea pigs having a new form of experimental allergic encephalomyelitis. / Bourdette, Dennis; Driscoll, Bernard F.; Seil, Fredrick J.; Kies, Marian W.; Alvord, Ellsworth C.

In: Neurochemical Pathology, Vol. 4, No. 1, 02.1986, p. 1-9.

Research output: Contribution to journalArticle

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