Severe dengue epidemics in Sri Lanka, 2003-2006

Nalaka Kanakaratne, Wahala M P B Wahala, William Messer, Hasitha A. Tissera, Aruna Shahani, Nihal Abeysinghe, Aravinda M. De Silva, Maya Gunasekera

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Recent emergence of dengue hemorrhagic fever in the Indian subcontinent has been well documented in Sri Lanka. We compare recent (2003-2006) and past (1980-1997) dengue surveillance data for Sri Lanka. The 4 dengue virus (DENV) serotypes have been cocirculating in Sri Lanka for >30 years. Over this period, a new genotype of DENV-1 has replaced an old genotype. Moreover, new clades of DENV-3 genotype III viruses have replaced older clades. Emergence of new clades of DENV-3 in 1989 and 2000 coincided with abrupt increases in the number of reported dengue cases, implicating this serotype in severe epidemics. In 1980-1997, most reported dengue cases were in children. Recent epidemics have been characterized by many cases in children and adults. Changes in local transmission dynamics and genetic changes in DENV-3 are likely increasing emergence of severe dengue epidemics in Sri Lanka.

Original languageEnglish (US)
Pages (from-to)192-199
Number of pages8
JournalEmerging Infectious Diseases
Volume15
Issue number2
DOIs
StatePublished - Feb 2009
Externally publishedYes

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Severe Dengue
Sri Lanka
Dengue Virus
Dengue
Genotype
Viruses

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Epidemiology

Cite this

Kanakaratne, N., Wahala, W. M. P. B., Messer, W., Tissera, H. A., Shahani, A., Abeysinghe, N., ... Gunasekera, M. (2009). Severe dengue epidemics in Sri Lanka, 2003-2006. Emerging Infectious Diseases, 15(2), 192-199. https://doi.org/10.3201/eid1502.080926

Severe dengue epidemics in Sri Lanka, 2003-2006. / Kanakaratne, Nalaka; Wahala, Wahala M P B; Messer, William; Tissera, Hasitha A.; Shahani, Aruna; Abeysinghe, Nihal; De Silva, Aravinda M.; Gunasekera, Maya.

In: Emerging Infectious Diseases, Vol. 15, No. 2, 02.2009, p. 192-199.

Research output: Contribution to journalArticle

Kanakaratne, N, Wahala, WMPB, Messer, W, Tissera, HA, Shahani, A, Abeysinghe, N, De Silva, AM & Gunasekera, M 2009, 'Severe dengue epidemics in Sri Lanka, 2003-2006', Emerging Infectious Diseases, vol. 15, no. 2, pp. 192-199. https://doi.org/10.3201/eid1502.080926
Kanakaratne N, Wahala WMPB, Messer W, Tissera HA, Shahani A, Abeysinghe N et al. Severe dengue epidemics in Sri Lanka, 2003-2006. Emerging Infectious Diseases. 2009 Feb;15(2):192-199. https://doi.org/10.3201/eid1502.080926
Kanakaratne, Nalaka ; Wahala, Wahala M P B ; Messer, William ; Tissera, Hasitha A. ; Shahani, Aruna ; Abeysinghe, Nihal ; De Silva, Aravinda M. ; Gunasekera, Maya. / Severe dengue epidemics in Sri Lanka, 2003-2006. In: Emerging Infectious Diseases. 2009 ; Vol. 15, No. 2. pp. 192-199.
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