Seven polymorphic loci mapping to human chromosomal region 11q22-qter

Cheryl Maslen, Carol Jones, Thomas Glaser, R. Ellen Magenis, Robert Sheehy, Jill Kellogg, Michael Litt

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    Seven polymorphic loci that map to human chromosomal region 11q22-qter are revealed by DNA probes isolated from a chromosome-specific phage library constructed from a human × mouse somatic cell hybrid that has retained an 11q;16q translocation as the only human DNA. Three probes, each of which reveals a two-allele polymorphism, and four probes, each of which detects two linked RFLPs, have been characterized. Using a somatic cell hybrid mapping panel that divides 11q into four discrete sections, the seven clones have been localized to specific chromosomal regions. Localization of one of the clones has been confirmed and refined by in situ hybridization.

    Original languageEnglish (US)
    Pages (from-to)66-75
    Number of pages10
    JournalGenomics
    Volume2
    Issue number1
    DOIs
    StatePublished - 1988

    Fingerprint

    Hybrid Cells
    Clone Cells
    DNA Probes
    Restriction Fragment Length Polymorphisms
    Bacteriophages
    In Situ Hybridization
    Chromosomes
    Alleles
    DNA

    ASJC Scopus subject areas

    • Genetics

    Cite this

    Maslen, C., Jones, C., Glaser, T., Magenis, R. E., Sheehy, R., Kellogg, J., & Litt, M. (1988). Seven polymorphic loci mapping to human chromosomal region 11q22-qter. Genomics, 2(1), 66-75. https://doi.org/10.1016/0888-7543(88)90110-3

    Seven polymorphic loci mapping to human chromosomal region 11q22-qter. / Maslen, Cheryl; Jones, Carol; Glaser, Thomas; Magenis, R. Ellen; Sheehy, Robert; Kellogg, Jill; Litt, Michael.

    In: Genomics, Vol. 2, No. 1, 1988, p. 66-75.

    Research output: Contribution to journalArticle

    Maslen, C, Jones, C, Glaser, T, Magenis, RE, Sheehy, R, Kellogg, J & Litt, M 1988, 'Seven polymorphic loci mapping to human chromosomal region 11q22-qter', Genomics, vol. 2, no. 1, pp. 66-75. https://doi.org/10.1016/0888-7543(88)90110-3
    Maslen, Cheryl ; Jones, Carol ; Glaser, Thomas ; Magenis, R. Ellen ; Sheehy, Robert ; Kellogg, Jill ; Litt, Michael. / Seven polymorphic loci mapping to human chromosomal region 11q22-qter. In: Genomics. 1988 ; Vol. 2, No. 1. pp. 66-75.
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