Seven newly identified loci for autoimmune thyroid disease

Wellcome Trust Case Control Consortium

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip. The SNP array contains all known and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-mediated diseases. After stringent quality control, we analysed 103 875 common SNPs (minor allele frequency >0.05) in 2285 GD and 462 HT patients and 9364 controls. We found evidence for seven new AITD risk loci (P < 1.12 × 10-6; a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases.

Original languageEnglish (US)
Pages (from-to)5202-5208
Number of pages7
JournalHuman molecular genetics
Volume21
Issue number23
DOIs
StatePublished - Dec 1 2012
Externally publishedYes

Fingerprint

Thyroid Diseases
Autoimmune Diseases
Single Nucleotide Polymorphism
Immune System Diseases
Hashimoto Disease
Graves Disease
Gene Frequency
Quality Control
Genotype

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Seven newly identified loci for autoimmune thyroid disease. / Wellcome Trust Case Control Consortium.

In: Human molecular genetics, Vol. 21, No. 23, 01.12.2012, p. 5202-5208.

Research output: Contribution to journalArticle

Wellcome Trust Case Control Consortium 2012, 'Seven newly identified loci for autoimmune thyroid disease', Human molecular genetics, vol. 21, no. 23, pp. 5202-5208. https://doi.org/10.1093/hmg/dds357
Wellcome Trust Case Control Consortium. / Seven newly identified loci for autoimmune thyroid disease. In: Human molecular genetics. 2012 ; Vol. 21, No. 23. pp. 5202-5208.
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abstract = "Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip. The SNP array contains all known and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-mediated diseases. After stringent quality control, we analysed 103 875 common SNPs (minor allele frequency >0.05) in 2285 GD and 462 HT patients and 9364 controls. We found evidence for seven new AITD risk loci (P < 1.12 × 10-6; a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases.",
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N2 - Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip. The SNP array contains all known and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-mediated diseases. After stringent quality control, we analysed 103 875 common SNPs (minor allele frequency >0.05) in 2285 GD and 462 HT patients and 9364 controls. We found evidence for seven new AITD risk loci (P < 1.12 × 10-6; a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases.

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