TY - JOUR
T1 - Serum osteocalcin (BGP) Levels in normal men
T2 - A longitudinal evaluation reveals an age‐associated increase
AU - Orwoll, Eric S.
AU - Deftos, Leonard J.
PY - 1990/3
Y1 - 1990/3
N2 - Serum levels of bone gla protein (BGP) have been reported to increase with aging and hence to reflect an age‐related increase in bone remodeling activity. To evaluate the relationship between aging and serum BGP levels in a study of longitudinal design, we measured BGP concentrations in 77 normal men at 6 month intervals over a 3 year period. Mean BGP levels at the onset (4.95 ± 1.5 ng/ml) increased significantly during the study (p = 0.004), and the mean of individual BGP slopes was positive (0.38 ± 0.6 ng/ml per year, p = 0.0001). The rate of change in BGP was not related to serum creatinine levels or dietary calcium intake.
AB - Serum levels of bone gla protein (BGP) have been reported to increase with aging and hence to reflect an age‐related increase in bone remodeling activity. To evaluate the relationship between aging and serum BGP levels in a study of longitudinal design, we measured BGP concentrations in 77 normal men at 6 month intervals over a 3 year period. Mean BGP levels at the onset (4.95 ± 1.5 ng/ml) increased significantly during the study (p = 0.004), and the mean of individual BGP slopes was positive (0.38 ± 0.6 ng/ml per year, p = 0.0001). The rate of change in BGP was not related to serum creatinine levels or dietary calcium intake.
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U2 - 10.1002/jbmr.5650050309
DO - 10.1002/jbmr.5650050309
M3 - Article
C2 - 2333785
AN - SCOPUS:0025320402
VL - 5
SP - 259
EP - 262
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
SN - 0884-0431
IS - 3
ER -