Serum osteocalcin (BGP) Levels in normal men: A longitudinal evaluation reveals an age‐associated increase

Eric S. Orwoll, Leonard J. Deftos

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Serum levels of bone gla protein (BGP) have been reported to increase with aging and hence to reflect an age‐related increase in bone remodeling activity. To evaluate the relationship between aging and serum BGP levels in a study of longitudinal design, we measured BGP concentrations in 77 normal men at 6 month intervals over a 3 year period. Mean BGP levels at the onset (4.95 ± 1.5 ng/ml) increased significantly during the study (p = 0.004), and the mean of individual BGP slopes was positive (0.38 ± 0.6 ng/ml per year, p = 0.0001). The rate of change in BGP was not related to serum creatinine levels or dietary calcium intake.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalJournal of Bone and Mineral Research
Volume5
Issue number3
DOIs
StatePublished - Mar 1990

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

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