Serum osteocalcin (BGP) Levels in normal men: A longitudinal evaluation reveals an age‐associated increase

Eric S. Orwoll; Leonard J. Deftos

doi:10.1002/jbmr.5650050309

Serum osteocalcin (BGP) Levels in normal men: A longitudinal evaluation reveals an age‐associated increase

Eric S. Orwoll, Leonard J. Deftos

Endocrinology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Serum levels of bone gla protein (BGP) have been reported to increase with aging and hence to reflect an age‐related increase in bone remodeling activity. To evaluate the relationship between aging and serum BGP levels in a study of longitudinal design, we measured BGP concentrations in 77 normal men at 6 month intervals over a 3 year period. Mean BGP levels at the onset (4.95 ± 1.5 ng/ml) increased significantly during the study (p = 0.004), and the mean of individual BGP slopes was positive (0.38 ± 0.6 ng/ml per year, p = 0.0001). The rate of change in BGP was not related to serum creatinine levels or dietary calcium intake.

Original language	English (US)
Pages (from-to)	259-262
Number of pages	4
Journal	Journal of Bone and Mineral Research
Volume	5
Issue number	3
DOIs	https://doi.org/10.1002/jbmr.5650050309
State	Published - Mar 1990

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine

Access to Document

10.1002/jbmr.5650050309

Fingerprint Dive into the research topics of 'Serum osteocalcin (BGP) Levels in normal men: A longitudinal evaluation reveals an age‐associated increase'. Together they form a unique fingerprint.

Cite this

@article{9839a14f44f848969377c74060e2c0e4,

title = "Serum osteocalcin (BGP) Levels in normal men: A longitudinal evaluation reveals an age‐associated increase",

abstract = "Serum levels of bone gla protein (BGP) have been reported to increase with aging and hence to reflect an age‐related increase in bone remodeling activity. To evaluate the relationship between aging and serum BGP levels in a study of longitudinal design, we measured BGP concentrations in 77 normal men at 6 month intervals over a 3 year period. Mean BGP levels at the onset (4.95 ± 1.5 ng/ml) increased significantly during the study (p = 0.004), and the mean of individual BGP slopes was positive (0.38 ± 0.6 ng/ml per year, p = 0.0001). The rate of change in BGP was not related to serum creatinine levels or dietary calcium intake.",

author = "Orwoll, {Eric S.} and Deftos, {Leonard J.}",

year = "1990",

month = mar,

doi = "10.1002/jbmr.5650050309",

language = "English (US)",

volume = "5",

pages = "259--262",

journal = "Journal of Bone and Mineral Research",

issn = "0884-0431",

publisher = "Wiley-Blackwell",

number = "3",

}

TY - JOUR

T1 - Serum osteocalcin (BGP) Levels in normal men

T2 - A longitudinal evaluation reveals an age‐associated increase

AU - Orwoll, Eric S.

AU - Deftos, Leonard J.

PY - 1990/3

Y1 - 1990/3

N2 - Serum levels of bone gla protein (BGP) have been reported to increase with aging and hence to reflect an age‐related increase in bone remodeling activity. To evaluate the relationship between aging and serum BGP levels in a study of longitudinal design, we measured BGP concentrations in 77 normal men at 6 month intervals over a 3 year period. Mean BGP levels at the onset (4.95 ± 1.5 ng/ml) increased significantly during the study (p = 0.004), and the mean of individual BGP slopes was positive (0.38 ± 0.6 ng/ml per year, p = 0.0001). The rate of change in BGP was not related to serum creatinine levels or dietary calcium intake.

AB - Serum levels of bone gla protein (BGP) have been reported to increase with aging and hence to reflect an age‐related increase in bone remodeling activity. To evaluate the relationship between aging and serum BGP levels in a study of longitudinal design, we measured BGP concentrations in 77 normal men at 6 month intervals over a 3 year period. Mean BGP levels at the onset (4.95 ± 1.5 ng/ml) increased significantly during the study (p = 0.004), and the mean of individual BGP slopes was positive (0.38 ± 0.6 ng/ml per year, p = 0.0001). The rate of change in BGP was not related to serum creatinine levels or dietary calcium intake.

UR - http://www.scopus.com/inward/record.url?scp=0025320402&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025320402&partnerID=8YFLogxK

U2 - 10.1002/jbmr.5650050309

DO - 10.1002/jbmr.5650050309

M3 - Article

C2 - 2333785

AN - SCOPUS:0025320402

VL - 5

SP - 259

EP - 262

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

IS - 3

ER -