Serum micronutrients and cervical dysplasia in Southwestern American Indian women

A. S S Yeo, M. A. Schiff, G. Montoya, M. Masuk, L. Van Asselt-King, Thomas Becker

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We carried out a clinic-based case-control study to assess serum micronutrients as risk factors for cervical dysplasia among Southwestern American Indian women, a group with high rates of cervical preinvasive lesions. Cases were American Indian women with biopsy-proven cervical intraepithelial neoplasia (CIN I or CIN II/III). Controls were from the same Indian Health Service clinics with normal cervical epithelium. We interviewed women about histories of sexually transmitted diseases, sexual behavior, diet, hygienic practices, cigarette smoking, and reproductive factors. Laboratory assays included serum for retinol (vitamin A), ascorbic acid (vitamin C), α-tocopherol (vitamin E), and red blood cell folate levels, DNA for human papillomavirus (HPV) typing, and tests for other sexually transmitted diseases. The strongest risks for cervical dysplasia were associated with cervical HPV infection [odds ratio (OR) = 3.2, 95% confidence interval (CI) = 2.2-4.6 and OR = 7.9, 95% CI = 4.8-13.1 for CIN I and CIN II/III, respectively]. With adjustments made for HPV infection and other relevant confounders, subjects in the lowest serum retinol quartile were at increased risk of CIN I compared with women in the highest quartile (OR = 2.3, 95% CI = 1.3-4.1). The data suggest that low serum α-tocopherol was associated with CIN II/III, although the adjusted OR was not statistically significant (OR = 2.0, 95% CI = 0.9-4.8). Low serum ascorbic acid and red blood cell folate were not associated with cervical dysplasia.

Original languageEnglish (US)
Pages (from-to)141-150
Number of pages10
JournalNutrition and Cancer
Volume38
Issue number2
StatePublished - 2000

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Uterine Cervical Dysplasia
North American Indians
American Indians
Micronutrients
dietary minerals
odds ratio
Odds Ratio
Papillomaviridae
confidence interval
Confidence Intervals
Ascorbic Acid
vitamin A
sexually transmitted diseases
Serum
Tocopherols
Papillomavirus Infections
ascorbic acid
Sexually Transmitted Diseases
lissamine rhodamine B
Vitamin A

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Oncology
  • Food Science

Cite this

Yeo, A. S. S., Schiff, M. A., Montoya, G., Masuk, M., Van Asselt-King, L., & Becker, T. (2000). Serum micronutrients and cervical dysplasia in Southwestern American Indian women. Nutrition and Cancer, 38(2), 141-150.

Serum micronutrients and cervical dysplasia in Southwestern American Indian women. / Yeo, A. S S; Schiff, M. A.; Montoya, G.; Masuk, M.; Van Asselt-King, L.; Becker, Thomas.

In: Nutrition and Cancer, Vol. 38, No. 2, 2000, p. 141-150.

Research output: Contribution to journalArticle

Yeo, ASS, Schiff, MA, Montoya, G, Masuk, M, Van Asselt-King, L & Becker, T 2000, 'Serum micronutrients and cervical dysplasia in Southwestern American Indian women', Nutrition and Cancer, vol. 38, no. 2, pp. 141-150.
Yeo ASS, Schiff MA, Montoya G, Masuk M, Van Asselt-King L, Becker T. Serum micronutrients and cervical dysplasia in Southwestern American Indian women. Nutrition and Cancer. 2000;38(2):141-150.
Yeo, A. S S ; Schiff, M. A. ; Montoya, G. ; Masuk, M. ; Van Asselt-King, L. ; Becker, Thomas. / Serum micronutrients and cervical dysplasia in Southwestern American Indian women. In: Nutrition and Cancer. 2000 ; Vol. 38, No. 2. pp. 141-150.
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