Abstract
BACKGROUND: To examine whether maternal serum levels of müllerian-inhibiting substance (MIS) differ in Down's syndrome and unaffected pregnancies. METHODS: Case-control study was conducted using stored serum from an antenatal screening programme. Sera from 25 Down's syndrome pregnancies were retrieved from -20°C storage together with 125 unaffected controls individually matched for maternal age, weeks of gestation and duration of storage. Results were expressed in multiples of the gestation-specific median value (MoM) in controls. RESULTS: The median value in Down's syndrome pregnancies was 0.83 MoM (P = 0.77, two-tail Wilcoxon rank sum test). Among unaffected pregnancies, there was a statistically significant correlation between MIS and pregnancy-associated plasma protein-A (P < 0.05). MIS levels were elevated in pregnancies where assisted reproduction techniques had been used. CONCLUSION: There is no evidence for a substantial reduction in maternal serum MIS levels in Down's syndrome pregnancies. This study provides useful information regarding serum MIS levels in pregnancy.
Original language | English (US) |
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Pages (from-to) | 1017-1020 |
Number of pages | 4 |
Journal | Human Reproduction |
Volume | 22 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2007 |
Externally published | Yes |
Keywords
- Antenatal screening
- Down's syndrome
- MIS
- Marker
- Ovarian reserve
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology