Serum müllerian-inhibiting substance in Down's syndrome pregnancies

David Seifer, David T. MacLaughlin, Howard S. Cuckle

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

BACKGROUND: To examine whether maternal serum levels of müllerian-inhibiting substance (MIS) differ in Down's syndrome and unaffected pregnancies. METHODS: Case-control study was conducted using stored serum from an antenatal screening programme. Sera from 25 Down's syndrome pregnancies were retrieved from -20°C storage together with 125 unaffected controls individually matched for maternal age, weeks of gestation and duration of storage. Results were expressed in multiples of the gestation-specific median value (MoM) in controls. RESULTS: The median value in Down's syndrome pregnancies was 0.83 MoM (P = 0.77, two-tail Wilcoxon rank sum test). Among unaffected pregnancies, there was a statistically significant correlation between MIS and pregnancy-associated plasma protein-A (P <0.05). MIS levels were elevated in pregnancies where assisted reproduction techniques had been used. CONCLUSION: There is no evidence for a substantial reduction in maternal serum MIS levels in Down's syndrome pregnancies. This study provides useful information regarding serum MIS levels in pregnancy.

Original languageEnglish (US)
Pages (from-to)1017-1020
Number of pages4
JournalHuman Reproduction
Volume22
Issue number4
DOIs
StatePublished - Apr 2007
Externally publishedYes

Fingerprint

Down Syndrome
Pregnancy
Serum
Nonparametric Statistics
Mothers
Pregnancy-Associated Plasma Protein-A
Reproductive Techniques
Maternal Age
Prenatal Diagnosis
Case-Control Studies

Keywords

  • Antenatal screening
  • Down's syndrome
  • Marker
  • MIS
  • Ovarian reserve

ASJC Scopus subject areas

  • Developmental Biology
  • Physiology
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Serum müllerian-inhibiting substance in Down's syndrome pregnancies. / Seifer, David; MacLaughlin, David T.; Cuckle, Howard S.

In: Human Reproduction, Vol. 22, No. 4, 04.2007, p. 1017-1020.

Research output: Contribution to journalArticle

Seifer, D, MacLaughlin, DT & Cuckle, HS 2007, 'Serum müllerian-inhibiting substance in Down's syndrome pregnancies', Human Reproduction, vol. 22, no. 4, pp. 1017-1020. https://doi.org/10.1093/humrep/del497
Seifer, David ; MacLaughlin, David T. ; Cuckle, Howard S. / Serum müllerian-inhibiting substance in Down's syndrome pregnancies. In: Human Reproduction. 2007 ; Vol. 22, No. 4. pp. 1017-1020.
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