Serum Lysozyme in Mice with Induced Granulomas

Elliot Borak; Robert Taub; Osaman el-Khatib; Elliott Osserman; Peter R. Holt; Michael J. Goodman; Robert M. Bennett; Therese Kokocinski; Wortha Carter

doi:10.1056/NEJM197609092951117

Serum Lysozyme in Mice with Induced Granulomas

Elliot Borak, Robert Taub, Osaman el-Khatib, Elliott Osserman, Peter R. Holt, Michael J. Goodman, Robert M. Bennett, Therese Kokocinski, Wortha Carter

Research output: Contribution to journal › Letter › peer-review

1 Scopus citations

Abstract

To the Editor: Last year, Falchuk, Perrotto, and Isselbacher presented evidence that the concentration of lysozyme in the serum was elevated in patients with Crohn's disease and normal in ulcerative colitis¹and that the degree of elevation was related to activity of the disease.²Most other investigators have failed to corroborate these findings.³ ⁴ ⁵ ⁶ ⁷ ⁸although one study using the turbidimetric method for the enzyme measurement has indicated that an elevated level was suggestive of Crohn's disease.⁹The stimulus for the initial study was based upon the fact that monocytes secrete lysozyme and that diseases in which active tissue granulomas occur,.Â .Â .

Original language	English (US)
Pages (from-to)	623-624
Number of pages	2
Journal	New England Journal of Medicine
Volume	295
Issue number	11
DOIs	https://doi.org/10.1056/NEJM197609092951117
State	Published - Sep 9 1976
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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title = "Serum Lysozyme in Mice with Induced Granulomas",

abstract = "To the Editor: Last year, Falchuk, Perrotto, and Isselbacher presented evidence that the concentration of lysozyme in the serum was elevated in patients with Crohn's disease and normal in ulcerative colitis1and that the degree of elevation was related to activity of the disease.2Most other investigators have failed to corroborate these findings.3 4 5 6 7 8although one study using the turbidimetric method for the enzyme measurement has indicated that an elevated level was suggestive of Crohn's disease.9The stimulus for the initial study was based upon the fact that monocytes secrete lysozyme and that diseases in which active tissue granulomas occur,.{\^A} .{\^A} .",

author = "Elliot Borak and Robert Taub and Osaman el-Khatib and Elliott Osserman and Holt, {Peter R.} and Goodman, {Michael J.} and Bennett, {Robert M.} and Therese Kokocinski and Wortha Carter",

year = "1976",

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language = "English (US)",

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TY - JOUR

T1 - Serum Lysozyme in Mice with Induced Granulomas

AU - Borak, Elliot

AU - Taub, Robert

AU - el-Khatib, Osaman

AU - Osserman, Elliott

AU - Holt, Peter R.

AU - Goodman, Michael J.

AU - Bennett, Robert M.

AU - Kokocinski, Therese

AU - Carter, Wortha

PY - 1976/9/9

Y1 - 1976/9/9

N2 - To the Editor: Last year, Falchuk, Perrotto, and Isselbacher presented evidence that the concentration of lysozyme in the serum was elevated in patients with Crohn's disease and normal in ulcerative colitis1and that the degree of elevation was related to activity of the disease.2Most other investigators have failed to corroborate these findings.3 4 5 6 7 8although one study using the turbidimetric method for the enzyme measurement has indicated that an elevated level was suggestive of Crohn's disease.9The stimulus for the initial study was based upon the fact that monocytes secrete lysozyme and that diseases in which active tissue granulomas occur,.Â .Â .

AB - To the Editor: Last year, Falchuk, Perrotto, and Isselbacher presented evidence that the concentration of lysozyme in the serum was elevated in patients with Crohn's disease and normal in ulcerative colitis1and that the degree of elevation was related to activity of the disease.2Most other investigators have failed to corroborate these findings.3 4 5 6 7 8although one study using the turbidimetric method for the enzyme measurement has indicated that an elevated level was suggestive of Crohn's disease.9The stimulus for the initial study was based upon the fact that monocytes secrete lysozyme and that diseases in which active tissue granulomas occur,.Â .Â .

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Serum Lysozyme in Mice with Induced Granulomas

Abstract

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