Serum Lysozyme in Mice with Induced Granulomas

Elliot Borak, Robert Taub, Osaman el-Khatib, Elliott Osserman, Peter R. Holt, Michael J. Goodman, Robert M. Bennett, Therese Kokocinski, Wortha Carter

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    Abstract

    To the Editor: Last year, Falchuk, Perrotto, and Isselbacher presented evidence that the concentration of lysozyme in the serum was elevated in patients with Crohn's disease and normal in ulcerative colitis1and that the degree of elevation was related to activity of the disease.2Most other investigators have failed to corroborate these findings.3 4 5 6 7 8although one study using the turbidimetric method for the enzyme measurement has indicated that an elevated level was suggestive of Crohn's disease.9The stimulus for the initial study was based upon the fact that monocytes secrete lysozyme and that diseases in which active tissue granulomas occur,. . .

    Original languageEnglish (US)
    Pages (from-to)623-624
    Number of pages2
    JournalNew England Journal of Medicine
    Volume295
    Issue number11
    DOIs
    StatePublished - Sep 9 1976

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    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Borak, E., Taub, R., el-Khatib, O., Osserman, E., Holt, P. R., Goodman, M. J., Bennett, R. M., Kokocinski, T., & Carter, W. (1976). Serum Lysozyme in Mice with Induced Granulomas. New England Journal of Medicine, 295(11), 623-624. https://doi.org/10.1056/NEJM197609092951117