Serum lipoprotein disturbances in primary and secondary hyperparathyroidism and effects of parathyroidectomy

B. Lacour, Jean-Baptiste Roullet, A. M. Liagre, V. Jorgetti, P. Beyne, C. Dubost, T. Drüeke

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Abstract

Serum lipoprotein disturbances were studied in 86 patients with primary (I°), and 34 hemodialysis patients with severe secondary (II°), hyperparathyroidism (HPTH) before and seven to 14 days after parathyroidectomy (PTx). In addition, a subset of patients had repeat studies more than 12 months after PTx. In patients with I° as well as with II° HPTH, mean ± SEM fasting serum concentrations of total triglycerides (TG) (1.51 ± 0.09 and 2.17 ± 0.19 mmol/L, respectively) were significantly increased when compared with that of 22 age- and sex-matched healthy control subjects (1.01 ± 0.09 mmol/L, P <.001). No consistent anomalies of serum total cholesterol and lipoprotein cholesterol content were observed in I° HPTH patients. In uremic II° HPTH patients, the cholesterol content of high-density lipoprotein (HDL) was significantly (P<.01) depresses, compared with normal subjects. In the short term, PTx normalized serum total TGs (P<.001) in 1 ° HPTH patients from 1.50 ± 0.11 to 1.19 ± 0.07 mmol/L seven days after PTx. The surgical correction of II° HPTH in dialysis patients was also followed by an improvement of hypertriglyceridemia from 2.22 ± 0.21 to 1.46 ± 0.08 mmol/L and 1.46 ± 0.09 mmol/L seven and 14 days, respectively, after PTx (P <.01). Long-term follow-up after PTx shows clearly a persistent decrease in serum TG concentration in I° HPTH patients (1.17 ± 0.11 mmol/L), as well as in II° HPTH patients (1.61 ± 0.18 mmol/L), 12 months after PTx by comparison with values determined before PTx. The other lipid parameters that were changed during the short-term follow-up after surgery were not found significantly modified 1 year after PTx. In conclusion, both I° and II° HPTH has associated disturbances of triglyceride metabolism that can be corrected by PTx.

Original languageEnglish (US)
Pages (from-to)422-429
Number of pages8
JournalAmerican Journal of Kidney Diseases
Volume8
Issue number6
StatePublished - 1986
Externally publishedYes

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Parathyroidectomy
Secondary Hyperparathyroidism
Primary Hyperparathyroidism
Lipoproteins
Hyperparathyroidism
Serum
Triglycerides
Hypertriglyceridemia
HDL Cholesterol
Renal Dialysis
Dialysis
Fasting
Healthy Volunteers
Cholesterol
Lipids

ASJC Scopus subject areas

  • Nephrology

Cite this

Lacour, B., Roullet, J-B., Liagre, A. M., Jorgetti, V., Beyne, P., Dubost, C., & Drüeke, T. (1986). Serum lipoprotein disturbances in primary and secondary hyperparathyroidism and effects of parathyroidectomy. American Journal of Kidney Diseases, 8(6), 422-429.

Serum lipoprotein disturbances in primary and secondary hyperparathyroidism and effects of parathyroidectomy. / Lacour, B.; Roullet, Jean-Baptiste; Liagre, A. M.; Jorgetti, V.; Beyne, P.; Dubost, C.; Drüeke, T.

In: American Journal of Kidney Diseases, Vol. 8, No. 6, 1986, p. 422-429.

Research output: Contribution to journalArticle

Lacour, B, Roullet, J-B, Liagre, AM, Jorgetti, V, Beyne, P, Dubost, C & Drüeke, T 1986, 'Serum lipoprotein disturbances in primary and secondary hyperparathyroidism and effects of parathyroidectomy', American Journal of Kidney Diseases, vol. 8, no. 6, pp. 422-429.
Lacour, B. ; Roullet, Jean-Baptiste ; Liagre, A. M. ; Jorgetti, V. ; Beyne, P. ; Dubost, C. ; Drüeke, T. / Serum lipoprotein disturbances in primary and secondary hyperparathyroidism and effects of parathyroidectomy. In: American Journal of Kidney Diseases. 1986 ; Vol. 8, No. 6. pp. 422-429.
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AU - Roullet, Jean-Baptiste

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AU - Jorgetti, V.

AU - Beyne, P.

AU - Dubost, C.

AU - Drüeke, T.

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AB - Serum lipoprotein disturbances were studied in 86 patients with primary (I°), and 34 hemodialysis patients with severe secondary (II°), hyperparathyroidism (HPTH) before and seven to 14 days after parathyroidectomy (PTx). In addition, a subset of patients had repeat studies more than 12 months after PTx. In patients with I° as well as with II° HPTH, mean ± SEM fasting serum concentrations of total triglycerides (TG) (1.51 ± 0.09 and 2.17 ± 0.19 mmol/L, respectively) were significantly increased when compared with that of 22 age- and sex-matched healthy control subjects (1.01 ± 0.09 mmol/L, P <.001). No consistent anomalies of serum total cholesterol and lipoprotein cholesterol content were observed in I° HPTH patients. In uremic II° HPTH patients, the cholesterol content of high-density lipoprotein (HDL) was significantly (P<.01) depresses, compared with normal subjects. In the short term, PTx normalized serum total TGs (P<.001) in 1 ° HPTH patients from 1.50 ± 0.11 to 1.19 ± 0.07 mmol/L seven days after PTx. The surgical correction of II° HPTH in dialysis patients was also followed by an improvement of hypertriglyceridemia from 2.22 ± 0.21 to 1.46 ± 0.08 mmol/L and 1.46 ± 0.09 mmol/L seven and 14 days, respectively, after PTx (P <.01). Long-term follow-up after PTx shows clearly a persistent decrease in serum TG concentration in I° HPTH patients (1.17 ± 0.11 mmol/L), as well as in II° HPTH patients (1.61 ± 0.18 mmol/L), 12 months after PTx by comparison with values determined before PTx. The other lipid parameters that were changed during the short-term follow-up after surgery were not found significantly modified 1 year after PTx. In conclusion, both I° and II° HPTH has associated disturbances of triglyceride metabolism that can be corrected by PTx.

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