Serum levels of insulin-like growth factor binding proteins in Ecuadorean children with growth hormone insensitivity

C. P. Burren, D. Wanek, S. Mohan, P. Cohen, J. Guevara-Aguirre, R. G. Rosenfeld

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Although insulin-like growth factor binding proteins (IGFBPs) are known to be important modulators of the action of insulin-like growth factors (IGFs), regulation of their production in vivo is not completely understood. Serum concentrations of IGFBP-3, -4 and -5 and acid-labile subunit (ALS) were therefore examined in 20 children with growth hormone (GH) insensitivity before and after 6 months of therapy with recombinant human IGF-I (80 or 120 μg/kg twice daily). The IGFBP concentrations in these children were compared with those in 62 GH-deficient children receiving GH therapy for 3 months. Serum levels of IGFBP-3, -4 and -5 and ALS all increased significantly (p < 0.0001) in GH-deficient children in response to GH therapy, whereas no significant increases occurred in the children with GH insensitivity. These findings indicate that GH is responsible for the regulation of serum levels of IGFBP-3, -4 and -5 and ALS, and that IGF-I does not directly regulate the concentrations of these circulating IGFBPs.

Original languageEnglish (US)
Pages (from-to)185-191
Number of pages7
JournalActa Paediatrica, International Journal of Paediatrics, Supplement
Volume88
Issue number428
StatePublished - Mar 11 1999

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Keywords

  • Growth hormone
  • Growth hormone insensitivity
  • Insulin-like growth factor I
  • Insulin-like growth factor binding protein

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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