Serum Levels of α-Klotho Are Correlated with Cerebrospinal Fluid Levels and Predict Measures of Cognitive Function

Payel Kundu, Benjamin Zimmerman, Joseph Quinn, Jeffrey Kaye, Nora Mattek, Shawn K. Westaway, Jacob Raber

Research output: Contribution to journalArticlepeer-review

Abstract

Background: α-klotho might play a role in neurodegenerative diseases. Objective: To determine levels of α-klotho and apoE in serum and cerebrospinal fluid (CSF) samples and their relationship with the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating (CDR). Methods: All subjects were between age 39 to 83+ (n = 94). CDR and MMSE were administered to all participants. CSF was collected in the early afternoon by lumbar puncture. Results: Serum and CSF levels of α-klotho are positively correlated and both predict scores on the MMSE and CDR, regardless of sex or apoE4 status. Conclusion: Our results demonstrate that α-klotho may be an important biomarker of cognitive health and neurodegeneration, and that relatively non-invasive sampling of α-klotho from serum is likely highly reflective of CSF levels.

Original languageEnglish (US)
Pages (from-to)1471-1481
Number of pages11
JournalJournal of Alzheimer's Disease
Volume86
Issue number3
DOIs
StatePublished - 2022

Keywords

  • apoE
  • cerebrospinal fluid
  • Clinical Dementia Rating
  • Mini-Mental State Examination
  • serum
  • α-klotho

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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