Serum iron increases with acute induction of hepatic heme oxygenase-1 in mice

Volker Mostert, Akihiro Nakayama, Lori M. Austin, Ximena Levander, Christopher D. Ferris, Kristina E. Hill, Raymond F. Burk

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Heme oxygenase (HO)-1 is induced by oxidative stress and protects against oxidant injury. We examined the effect of rapid induction of hepatic HO-1 on serum iron level. Serum iron was approximately doubled within 6 h when HO-1 was induced by phenobarbital treatment of selenium-deficient mice. Blocking heme synthesis with diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (DDC) prevented the induction of HO-1 and the rise in serum iron. DDC did not block HO-1 induction by hemin. Inhibition of HO activity by tin protoporphyrin prevented a rise in serum iron that occurred following phorone treatment. These results indicate that heme synthesis or an exogenous source of heme is needed to allow induction of HO-1. Further, they link HO-1 induction with a rise in serum iron, suggesting that the iron resulting from catabolism of heme by HO-1 is released by the liver.

Original languageEnglish (US)
Pages (from-to)619-626
Number of pages8
JournalDrug Metabolism Reviews
Volume39
Issue number2-3
DOIs
StatePublished - Apr 2007
Externally publishedYes

Fingerprint

Heme Oxygenase-1
Iron
Liver
Serum
Heme
Heme Oxygenase (Decyclizing)
Hemin
Phenobarbital
Selenium
Oxidants
Oxidative Stress
Wounds and Injuries

Keywords

  • Heme
  • Heme oxygenase-1
  • Heme synthesis
  • Iron export
  • Oxidative stress
  • Selenium deficiency

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Cite this

Mostert, V., Nakayama, A., Austin, L. M., Levander, X., Ferris, C. D., Hill, K. E., & Burk, R. F. (2007). Serum iron increases with acute induction of hepatic heme oxygenase-1 in mice. Drug Metabolism Reviews, 39(2-3), 619-626. https://doi.org/10.1080/03602530701468342

Serum iron increases with acute induction of hepatic heme oxygenase-1 in mice. / Mostert, Volker; Nakayama, Akihiro; Austin, Lori M.; Levander, Ximena; Ferris, Christopher D.; Hill, Kristina E.; Burk, Raymond F.

In: Drug Metabolism Reviews, Vol. 39, No. 2-3, 04.2007, p. 619-626.

Research output: Contribution to journalArticle

Mostert, V, Nakayama, A, Austin, LM, Levander, X, Ferris, CD, Hill, KE & Burk, RF 2007, 'Serum iron increases with acute induction of hepatic heme oxygenase-1 in mice', Drug Metabolism Reviews, vol. 39, no. 2-3, pp. 619-626. https://doi.org/10.1080/03602530701468342
Mostert, Volker ; Nakayama, Akihiro ; Austin, Lori M. ; Levander, Ximena ; Ferris, Christopher D. ; Hill, Kristina E. ; Burk, Raymond F. / Serum iron increases with acute induction of hepatic heme oxygenase-1 in mice. In: Drug Metabolism Reviews. 2007 ; Vol. 39, No. 2-3. pp. 619-626.
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