Serum insulin-like growth factor-I concentration is associated with leukocyte telomere length in a population-based cohort of elderly men

Sofia Movérare-Skrtic, Johan Svensson, Magnus K. Karlsson, Eric Orwoll, Östen Ljunggren, Dan Mellström, Claes Ohlsson

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Context: Both leukocyte telomere length and IGF-I are associated with the aging process. A previous in vitro study suggested that IGF-I may modulate telomerase activity in white blood cells, but little is known whether these two systems interact in vivo. Patients and Methods: Leukocyte telomere length was determined using a quantitative PCR assay in 2744 elderly men (mean age 75.5 yr, range 69-81 yr) included in the population-based Osteoporotic Fractures in Men-Sweden study. Serum IGF-I concentration was measured using RIA. Results: Subjects with a leukocyte telomere length in the lowest tertile group had lower serum IGF-I concentration than subjects in the two tertile groups with longer telomere lengths (P = 0.005). Logistic regression analyses showed that a higher serum IGF-I concentration was associated with a significantly reduced risk of having a leukocyte telomere length in the lowest tertile group and also after adjustment for multiple covariates (P <0.01). Multivariate linear regression analyses demonstrated that tertile of leukocyte telomere length was positively, whereas age was negatively, associated with serum IGF-I concentration in elderly men. Conclusions: In this large population-based, cross-sectional study, leukocyte telomere length was positively associated with serum IGF-I concentration in elderly men. The mechanisms underlying the association between serum IGF-I concentration and leukocyte telomere length remain to be determined.

Original languageEnglish (US)
Pages (from-to)5078-5084
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume94
Issue number12
DOIs
StatePublished - Dec 2009

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Telomere
Insulin-Like Growth Factor I
Leukocytes
Serum
Population
Regression Analysis
Osteoporotic Fractures
Telomerase
Linear regression
Sweden
Logistics
Linear Models
Assays
Blood
Cross-Sectional Studies
Aging of materials
Logistic Models
Cells
Association reactions
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Serum insulin-like growth factor-I concentration is associated with leukocyte telomere length in a population-based cohort of elderly men. / Movérare-Skrtic, Sofia; Svensson, Johan; Karlsson, Magnus K.; Orwoll, Eric; Ljunggren, Östen; Mellström, Dan; Ohlsson, Claes.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 12, 12.2009, p. 5078-5084.

Research output: Contribution to journalArticle

Movérare-Skrtic, Sofia ; Svensson, Johan ; Karlsson, Magnus K. ; Orwoll, Eric ; Ljunggren, Östen ; Mellström, Dan ; Ohlsson, Claes. / Serum insulin-like growth factor-I concentration is associated with leukocyte telomere length in a population-based cohort of elderly men. In: Journal of Clinical Endocrinology and Metabolism. 2009 ; Vol. 94, No. 12. pp. 5078-5084.
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