Serum inhibin levels are lower in ectopic than intrauterine spontaneously conceived pregnancies

D. B. Seifer, G. N. Frishman, G. M. Lambert-Messerlian, A. L. Schneyer, J. A. Canick

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Objective: To determine if serum inhibin concentrations are lower in ectopic (EP) versus intrauterine pregnancies (IUPs) that are conceived spontaneously. Design: Case-control study. Setting: Academic clinical practice. Patients: Serum samples were obtained from 19 women who bad EP confirmed at surgery and by pathology. For comparison, serum samples were collected from 24 women of similar chronological and gestational age with sonographic evidence of an IUP. Main Outcome Measure: Serum dimeric inhibin- A, total inhibin, P, and hCG. Results: Serum total and dimeric inhibin concentrations in women with EP were <60% of the concentrations for women with single IUPs. Total inhibin, but not dimeric inhibin-A, was elevated in maternal serum before week 8 of gestation relative to normal menstrual cycle levels. Conclusions: Serum inhibin concentrations are lower in EP as compared with IUPs that are spontaneously conceived and the relative amounts of dimeric inhibin-A, B, and α inhibin subunit in maternal serum may change throughout gestation.

Original languageEnglish (US)
Pages (from-to)667-669
Number of pages3
JournalFertility and sterility
Issue number3
StatePublished - Jan 1 1996


  • Ectopic
  • serum dimeric inhibin
  • serum total inhibin

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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