Serum IGF-1 in the diagnosis of acromegaly and the profile of patients with elevated igf-1 but normal glucose-suppressed growth hormone

Sreevidya K. Subbarayan, Maria Fleseriu, Murray B. Gordon, Jessica A. Brzana, Laurence Kennedy, Charles Faiman, Betul A. Hatipoglu, Richard A. Prayson, Johnny B. Delashaw, Robert J. Weil, Amir H. Hamrahian

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10 Scopus citations

Abstract

Objective: To report the utility of insulin-like growth factor-1 (IGF-1) as a single biomarker for establishing the diagnosis of acromegaly and to examine the clinical and biochemical profile of patients with an elevated IGF-1 in whom a diagnosis of acromegaly could not be confirmed by means of the oral glucose tolerance test (OGTT). Methods: Between the years 1999 and 2010, we identified 101 patients who underwent pituitary surgery and had histologically proven somatotroph adenomas (Group 1, Gr 1). We selected 149 patients with non-growth hormone (GH) secreting pituitary macroadenomas (Gr 2, n = 97) and microadenomas (Gr 3, n = 52) to serve as control subjects. In addition, we identified 34 patients with elevated IGF-1values in whom acromegaly could not subsequently be proven by the OGTT (Gr 4). Results: IGF-1 was elevated in all patients with acromegaly prior to therapy with a median (range) standard deviation score (SDS) of +9.52 (+2.34 to +9.2), compared to SDS -1.46 (-2.91 to +2.17) and -1.22 (-2.8 to +1.58) in Gr 2 and 3, respectively (P<0.001). IGF-1 SDS values were +3.28 (+2.05 to +6.1), and IGF-1 was less than twice the upper limit of normal in all patients in Gr 4. OGTT was performed in 51 of the 101 acromegalic patients. The nadir GH in these patients was 4.01 (0.2 to 46.7) in comparison with 0.2 (<0.05 to 0.6) in Gr 4 (P<0.001). Conclusion: Elevated IGF-1 levels, alone, are sufficient to establish a diagnosis of acromegaly in the majority of clinically suspected cases. The OGTT may be useful to obtain corroborative evidence when there is modest elevation of IGF-1 with absent or equivocal clinical features.

Original languageEnglish (US)
Pages (from-to)817-825
Number of pages9
JournalEndocrine Practice
Volume18
Issue number6
DOIs
StatePublished - Nov 1 2012

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Subbarayan, S. K., Fleseriu, M., Gordon, M. B., Brzana, J. A., Kennedy, L., Faiman, C., Hatipoglu, B. A., Prayson, R. A., Delashaw, J. B., Weil, R. J., & Hamrahian, A. H. (2012). Serum IGF-1 in the diagnosis of acromegaly and the profile of patients with elevated igf-1 but normal glucose-suppressed growth hormone. Endocrine Practice, 18(6), 817-825. https://doi.org/10.4158/EP11324.OR