Serum free thyroxine values in term, premature, and sick infants

Darrell M. Wilson; Andrew O. Hopper; I. Ross McDougall; Monika F. Bayer; Raymond L. Hintz; David K. Stevenson; Ron G. Rosenfeld

doi:10.1016/S0022-3476(82)80198-4

Serum free thyroxine values in term, premature, and sick infants

Darrell M. Wilson, Andrew O. Hopper, I. Ross McDougall, Monika F. Bayer, Raymond L. Hintz, David K. Stevenson, Ron G. Rosenfeld

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36 Scopus citations

Abstract

Free thyroxine concentrations were determined by radioimmunoassay in 96 infants within an intensive care nursery and in 32 healthy term infants. Sera for free T₄ levels were drawn simultaneously with the filter paper specimens for T₄ obtained to screen these infants for congenital hypothyroidism. The mean free T₄ level in 20 adults was 1.38±0.03 ng/dl (mean±SEM). The mean in the ICN infants was 3.48±0.18 ng/dl and in healthy term infants, 4.24±0.23 ng/dl. Like T₄, free T₄ correlated positively with increasing gestational age and birth weight, and was lower in infants with RDS. Although 66% of the ICN infants had T₄ levels below the statistically selected screening level (fifth percentile), all of these infants had free T₄ levels greater than 0.8 ng/dl. Two additional infants with untreated congenital hypothyroidism had free T₄ levels of 0.3 and 0.4 ng/dl. The measurement of free T₄ appears to be an accurate indicator of thyroid function in these infants.

Original language	English (US)
Pages (from-to)	113-117
Number of pages	5
Journal	The Journal of pediatrics
Volume	101
Issue number	1
DOIs	https://doi.org/10.1016/S0022-3476(82)80198-4
State	Published - Jul 1982
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/S0022-3476(82)80198-4

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title = "Serum free thyroxine values in term, premature, and sick infants",

abstract = "Free thyroxine concentrations were determined by radioimmunoassay in 96 infants within an intensive care nursery and in 32 healthy term infants. Sera for free T4 levels were drawn simultaneously with the filter paper specimens for T4 obtained to screen these infants for congenital hypothyroidism. The mean free T4 level in 20 adults was 1.38±0.03 ng/dl (mean±SEM). The mean in the ICN infants was 3.48±0.18 ng/dl and in healthy term infants, 4.24±0.23 ng/dl. Like T4, free T4 correlated positively with increasing gestational age and birth weight, and was lower in infants with RDS. Although 66% of the ICN infants had T4 levels below the statistically selected screening level (fifth percentile), all of these infants had free T4 levels greater than 0.8 ng/dl. Two additional infants with untreated congenital hypothyroidism had free T4 levels of 0.3 and 0.4 ng/dl. The measurement of free T4 appears to be an accurate indicator of thyroid function in these infants.",

author = "Wilson, {Darrell M.} and Hopper, {Andrew O.} and McDougall, {I. Ross} and Bayer, {Monika F.} and Hintz, {Raymond L.} and Stevenson, {David K.} and Rosenfeld, {Ron G.}",

note = "Funding Information: From the Departments of Pediatrics and Radiology, StanJord University Medical Center, Stanford University. Supported in part by a grant (RR-81) J?om GCRC Program of the Division of Research Sources, National Institutes of Health. *Reprint address: Department of Pediatrics, S-322 Medical Center, Stanford, CA 94305.",

year = "1982",

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doi = "10.1016/S0022-3476(82)80198-4",

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pages = "113--117",

journal = "The Journal of pediatrics",

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T1 - Serum free thyroxine values in term, premature, and sick infants

AU - Wilson, Darrell M.

AU - Hopper, Andrew O.

AU - McDougall, I. Ross

AU - Bayer, Monika F.

AU - Hintz, Raymond L.

AU - Stevenson, David K.

AU - Rosenfeld, Ron G.

N1 - Funding Information: From the Departments of Pediatrics and Radiology, StanJord University Medical Center, Stanford University. Supported in part by a grant (RR-81) J?om GCRC Program of the Division of Research Sources, National Institutes of Health. *Reprint address: Department of Pediatrics, S-322 Medical Center, Stanford, CA 94305.

PY - 1982/7

Y1 - 1982/7

N2 - Free thyroxine concentrations were determined by radioimmunoassay in 96 infants within an intensive care nursery and in 32 healthy term infants. Sera for free T4 levels were drawn simultaneously with the filter paper specimens for T4 obtained to screen these infants for congenital hypothyroidism. The mean free T4 level in 20 adults was 1.38±0.03 ng/dl (mean±SEM). The mean in the ICN infants was 3.48±0.18 ng/dl and in healthy term infants, 4.24±0.23 ng/dl. Like T4, free T4 correlated positively with increasing gestational age and birth weight, and was lower in infants with RDS. Although 66% of the ICN infants had T4 levels below the statistically selected screening level (fifth percentile), all of these infants had free T4 levels greater than 0.8 ng/dl. Two additional infants with untreated congenital hypothyroidism had free T4 levels of 0.3 and 0.4 ng/dl. The measurement of free T4 appears to be an accurate indicator of thyroid function in these infants.

AB - Free thyroxine concentrations were determined by radioimmunoassay in 96 infants within an intensive care nursery and in 32 healthy term infants. Sera for free T4 levels were drawn simultaneously with the filter paper specimens for T4 obtained to screen these infants for congenital hypothyroidism. The mean free T4 level in 20 adults was 1.38±0.03 ng/dl (mean±SEM). The mean in the ICN infants was 3.48±0.18 ng/dl and in healthy term infants, 4.24±0.23 ng/dl. Like T4, free T4 correlated positively with increasing gestational age and birth weight, and was lower in infants with RDS. Although 66% of the ICN infants had T4 levels below the statistically selected screening level (fifth percentile), all of these infants had free T4 levels greater than 0.8 ng/dl. Two additional infants with untreated congenital hypothyroidism had free T4 levels of 0.3 and 0.4 ng/dl. The measurement of free T4 appears to be an accurate indicator of thyroid function in these infants.

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Serum free thyroxine values in term, premature, and sick infants

Abstract

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