Serum Calcium and Risk of Sudden Cardiac Arrest in the General Population

Hirad Yarmohammadi, Audrey Uy-Evanado, Kyndaron Reinier, Carmen Rusinaru, Harpriya Chugh, Jonathan Jui, Sumeet S. Chugh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: To evaluate the potential role of low serum Ca levels in the occurrence of sudden cardiac arrest (SCA) in the community. Patients and Methods: We compared 267 SCA cases [177 (66%) men] and 445 controls [314 (71%) men] from a large population-based study (catchment population ∼1 million individuals) in the US Northwest from February 1, 2002, through December 31, 2015. Patients were included if their age was 18 years or older with available creatinine clearance (CrCl) and serum electrolyte levels for analyses to enable adjustment for renal function. For cases, creatinine clearance and electrolyte levels were required to be measured within 90 days of the SCA event. Results: Cases of SCA had higher proportions of blacks [31 (12%) vs 14 (3%); P<.001], diabetes mellitus [122 (46%) vs 126 (28%); P<.001], and chronic kidney disease [102 (38%) vs 73 (16%); P<.001] than did controls. In multivariable logistic regression analysis, a 1-unit decrease in Ca levels was associated with a 1.6-fold increase in odds of SCA (odds ratio, 1.63; 95% CI, 1.06-2.51). Blood Ca levels lower than 8.95 mg/dL (to convert to mmol/L, multiply by 0.025) were associated with a 2.3-fold increase in odds of SCA as compared with levels higher than 9.55 mg/dL (odds ratio, 2.33; 95% CI, 1.17-4.61). Cases of SCA had significantly prolonged corrected QT intervals on the 12-lead electrocardiogram than did controls (465±37 ms vs 425±33 ms; P<.001). Conclusion: Lower serum Ca levels were independently associated with an increased risk of SCA in the community.

Original languageEnglish (US)
JournalMayo Clinic Proceedings
DOIs
StateAccepted/In press - 2017

Fingerprint

Sudden Cardiac Death
Calcium
Serum
Population
Electrolytes
Creatinine
Odds Ratio
Northwestern United States
Chronic Renal Insufficiency
Diabetes Mellitus
Electrocardiography
Logistic Models
Regression Analysis
Kidney

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Yarmohammadi, H., Uy-Evanado, A., Reinier, K., Rusinaru, C., Chugh, H., Jui, J., & Chugh, S. S. (Accepted/In press). Serum Calcium and Risk of Sudden Cardiac Arrest in the General Population. Mayo Clinic Proceedings. https://doi.org/10.1016/j.mayocp.2017.05.028

Serum Calcium and Risk of Sudden Cardiac Arrest in the General Population. / Yarmohammadi, Hirad; Uy-Evanado, Audrey; Reinier, Kyndaron; Rusinaru, Carmen; Chugh, Harpriya; Jui, Jonathan; Chugh, Sumeet S.

In: Mayo Clinic Proceedings, 2017.

Research output: Contribution to journalArticle

Yarmohammadi, Hirad ; Uy-Evanado, Audrey ; Reinier, Kyndaron ; Rusinaru, Carmen ; Chugh, Harpriya ; Jui, Jonathan ; Chugh, Sumeet S. / Serum Calcium and Risk of Sudden Cardiac Arrest in the General Population. In: Mayo Clinic Proceedings. 2017.
@article{7a6d32ca53f642bab7d63e70b94e7647,
title = "Serum Calcium and Risk of Sudden Cardiac Arrest in the General Population",
abstract = "Objective: To evaluate the potential role of low serum Ca levels in the occurrence of sudden cardiac arrest (SCA) in the community. Patients and Methods: We compared 267 SCA cases [177 (66{\%}) men] and 445 controls [314 (71{\%}) men] from a large population-based study (catchment population ∼1 million individuals) in the US Northwest from February 1, 2002, through December 31, 2015. Patients were included if their age was 18 years or older with available creatinine clearance (CrCl) and serum electrolyte levels for analyses to enable adjustment for renal function. For cases, creatinine clearance and electrolyte levels were required to be measured within 90 days of the SCA event. Results: Cases of SCA had higher proportions of blacks [31 (12{\%}) vs 14 (3{\%}); P<.001], diabetes mellitus [122 (46{\%}) vs 126 (28{\%}); P<.001], and chronic kidney disease [102 (38{\%}) vs 73 (16{\%}); P<.001] than did controls. In multivariable logistic regression analysis, a 1-unit decrease in Ca levels was associated with a 1.6-fold increase in odds of SCA (odds ratio, 1.63; 95{\%} CI, 1.06-2.51). Blood Ca levels lower than 8.95 mg/dL (to convert to mmol/L, multiply by 0.025) were associated with a 2.3-fold increase in odds of SCA as compared with levels higher than 9.55 mg/dL (odds ratio, 2.33; 95{\%} CI, 1.17-4.61). Cases of SCA had significantly prolonged corrected QT intervals on the 12-lead electrocardiogram than did controls (465±37 ms vs 425±33 ms; P<.001). Conclusion: Lower serum Ca levels were independently associated with an increased risk of SCA in the community.",
author = "Hirad Yarmohammadi and Audrey Uy-Evanado and Kyndaron Reinier and Carmen Rusinaru and Harpriya Chugh and Jonathan Jui and Chugh, {Sumeet S.}",
year = "2017",
doi = "10.1016/j.mayocp.2017.05.028",
language = "English (US)",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",

}

TY - JOUR

T1 - Serum Calcium and Risk of Sudden Cardiac Arrest in the General Population

AU - Yarmohammadi, Hirad

AU - Uy-Evanado, Audrey

AU - Reinier, Kyndaron

AU - Rusinaru, Carmen

AU - Chugh, Harpriya

AU - Jui, Jonathan

AU - Chugh, Sumeet S.

PY - 2017

Y1 - 2017

N2 - Objective: To evaluate the potential role of low serum Ca levels in the occurrence of sudden cardiac arrest (SCA) in the community. Patients and Methods: We compared 267 SCA cases [177 (66%) men] and 445 controls [314 (71%) men] from a large population-based study (catchment population ∼1 million individuals) in the US Northwest from February 1, 2002, through December 31, 2015. Patients were included if their age was 18 years or older with available creatinine clearance (CrCl) and serum electrolyte levels for analyses to enable adjustment for renal function. For cases, creatinine clearance and electrolyte levels were required to be measured within 90 days of the SCA event. Results: Cases of SCA had higher proportions of blacks [31 (12%) vs 14 (3%); P<.001], diabetes mellitus [122 (46%) vs 126 (28%); P<.001], and chronic kidney disease [102 (38%) vs 73 (16%); P<.001] than did controls. In multivariable logistic regression analysis, a 1-unit decrease in Ca levels was associated with a 1.6-fold increase in odds of SCA (odds ratio, 1.63; 95% CI, 1.06-2.51). Blood Ca levels lower than 8.95 mg/dL (to convert to mmol/L, multiply by 0.025) were associated with a 2.3-fold increase in odds of SCA as compared with levels higher than 9.55 mg/dL (odds ratio, 2.33; 95% CI, 1.17-4.61). Cases of SCA had significantly prolonged corrected QT intervals on the 12-lead electrocardiogram than did controls (465±37 ms vs 425±33 ms; P<.001). Conclusion: Lower serum Ca levels were independently associated with an increased risk of SCA in the community.

AB - Objective: To evaluate the potential role of low serum Ca levels in the occurrence of sudden cardiac arrest (SCA) in the community. Patients and Methods: We compared 267 SCA cases [177 (66%) men] and 445 controls [314 (71%) men] from a large population-based study (catchment population ∼1 million individuals) in the US Northwest from February 1, 2002, through December 31, 2015. Patients were included if their age was 18 years or older with available creatinine clearance (CrCl) and serum electrolyte levels for analyses to enable adjustment for renal function. For cases, creatinine clearance and electrolyte levels were required to be measured within 90 days of the SCA event. Results: Cases of SCA had higher proportions of blacks [31 (12%) vs 14 (3%); P<.001], diabetes mellitus [122 (46%) vs 126 (28%); P<.001], and chronic kidney disease [102 (38%) vs 73 (16%); P<.001] than did controls. In multivariable logistic regression analysis, a 1-unit decrease in Ca levels was associated with a 1.6-fold increase in odds of SCA (odds ratio, 1.63; 95% CI, 1.06-2.51). Blood Ca levels lower than 8.95 mg/dL (to convert to mmol/L, multiply by 0.025) were associated with a 2.3-fold increase in odds of SCA as compared with levels higher than 9.55 mg/dL (odds ratio, 2.33; 95% CI, 1.17-4.61). Cases of SCA had significantly prolonged corrected QT intervals on the 12-lead electrocardiogram than did controls (465±37 ms vs 425±33 ms; P<.001). Conclusion: Lower serum Ca levels were independently associated with an increased risk of SCA in the community.

UR - http://www.scopus.com/inward/record.url?scp=85029698881&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029698881&partnerID=8YFLogxK

U2 - 10.1016/j.mayocp.2017.05.028

DO - 10.1016/j.mayocp.2017.05.028

M3 - Article

C2 - 28943016

AN - SCOPUS:85029698881

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

ER -