Serum biomarkers of inflammation and adiposity in the LABS cohort

associations with metabolic disease and surgical outcomes

Robert W. O’Rourke, Geoffrey S. Johnson, Jonathan Purnell, Anita P. Courcoulas, Gregory F. Dakin, Luis Garcia, Marcelo Hinojosa, James E. Mitchell, Alfons Pomp, Walter J. Pories, Konstantinos Spaniolas, David R. Flum, Abdus S. Wahed, Bruce Wolfe

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The utility of serum biomarkers related to inflammation and adiposity as predictors of metabolic disease prevalence and outcomes after bariatric surgery are not well-defined. Methods: Associations between pre- and post-operative serum levels of four biomarkers (C-reactive protein (CRP), cystatin C (CC), leptin, and ghrelin) with baseline measures of adiposity and metabolic disease prevalence (asthma, diabetes, sleep apnea), and weight loss and metabolic disease remission after bariatric surgery were studied in the Longitudinal Assessment of Bariatric Surgery (LABS) cohort. Results: Baseline CRP levels were positively associated with the odds of asthma but not diabetes or sleep apnea; baseline CC levels were positively associated with asthma, diabetes, and sleep apnea; baseline leptin levels were positively associated with asthma and negatively associated with diabetes and sleep apnea; baseline ghrelin levels were negatively associated with diabetes and sleep apnea. Increased weight loss was associated with increased baseline levels of leptin and CRP and decreased baseline levels of CC. Remission of diabetes and asthma was not associated with baseline levels of any biomarker. A higher likelihood of asthma remission was associated with a greater decrease in leptin levels, and a higher likelihood of diabetes remission was predicted by a lesser decrease in CC. Bariatric surgery was associated with decreased post-operative CC, CRP, and leptin levels, and increased post-operative ghrelin levels. Conclusion: This is the largest study to date of serum biomarkers of inflammation and adiposity in a bariatric surgery cohort. Biomarker levels correlate with metabolic disease prevalence prior to bariatric surgery, and with weight loss but not metabolic disease remission after surgery. Bariatric surgery regulates serum biomarker levels in a manner consistent with anti-inflammatory and compensatory orexigenic effects. These data contribute to our understanding of the mechanisms underlying the biologic effects of bariatric surgery.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalInternational Journal of Obesity
DOIs
StateAccepted/In press - May 17 2018

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Bariatric Surgery
Metabolic Diseases
Adiposity
Cystatin C
Biomarkers
Sleep Apnea Syndromes
Inflammation
Leptin
Asthma
Serum
C-Reactive Protein
Ghrelin
Weight Loss
Protein C
Anti-Inflammatory Agents

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Serum biomarkers of inflammation and adiposity in the LABS cohort : associations with metabolic disease and surgical outcomes. / O’Rourke, Robert W.; Johnson, Geoffrey S.; Purnell, Jonathan; Courcoulas, Anita P.; Dakin, Gregory F.; Garcia, Luis; Hinojosa, Marcelo; Mitchell, James E.; Pomp, Alfons; Pories, Walter J.; Spaniolas, Konstantinos; Flum, David R.; Wahed, Abdus S.; Wolfe, Bruce.

In: International Journal of Obesity, 17.05.2018, p. 1-12.

Research output: Contribution to journalArticle

O’Rourke, RW, Johnson, GS, Purnell, J, Courcoulas, AP, Dakin, GF, Garcia, L, Hinojosa, M, Mitchell, JE, Pomp, A, Pories, WJ, Spaniolas, K, Flum, DR, Wahed, AS & Wolfe, B 2018, 'Serum biomarkers of inflammation and adiposity in the LABS cohort: associations with metabolic disease and surgical outcomes', International Journal of Obesity, pp. 1-12. https://doi.org/10.1038/s41366-018-0088-z
O’Rourke, Robert W. ; Johnson, Geoffrey S. ; Purnell, Jonathan ; Courcoulas, Anita P. ; Dakin, Gregory F. ; Garcia, Luis ; Hinojosa, Marcelo ; Mitchell, James E. ; Pomp, Alfons ; Pories, Walter J. ; Spaniolas, Konstantinos ; Flum, David R. ; Wahed, Abdus S. ; Wolfe, Bruce. / Serum biomarkers of inflammation and adiposity in the LABS cohort : associations with metabolic disease and surgical outcomes. In: International Journal of Obesity. 2018 ; pp. 1-12.
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abstract = "Background: The utility of serum biomarkers related to inflammation and adiposity as predictors of metabolic disease prevalence and outcomes after bariatric surgery are not well-defined. Methods: Associations between pre- and post-operative serum levels of four biomarkers (C-reactive protein (CRP), cystatin C (CC), leptin, and ghrelin) with baseline measures of adiposity and metabolic disease prevalence (asthma, diabetes, sleep apnea), and weight loss and metabolic disease remission after bariatric surgery were studied in the Longitudinal Assessment of Bariatric Surgery (LABS) cohort. Results: Baseline CRP levels were positively associated with the odds of asthma but not diabetes or sleep apnea; baseline CC levels were positively associated with asthma, diabetes, and sleep apnea; baseline leptin levels were positively associated with asthma and negatively associated with diabetes and sleep apnea; baseline ghrelin levels were negatively associated with diabetes and sleep apnea. Increased weight loss was associated with increased baseline levels of leptin and CRP and decreased baseline levels of CC. Remission of diabetes and asthma was not associated with baseline levels of any biomarker. A higher likelihood of asthma remission was associated with a greater decrease in leptin levels, and a higher likelihood of diabetes remission was predicted by a lesser decrease in CC. Bariatric surgery was associated with decreased post-operative CC, CRP, and leptin levels, and increased post-operative ghrelin levels. Conclusion: This is the largest study to date of serum biomarkers of inflammation and adiposity in a bariatric surgery cohort. Biomarker levels correlate with metabolic disease prevalence prior to bariatric surgery, and with weight loss but not metabolic disease remission after surgery. Bariatric surgery regulates serum biomarker levels in a manner consistent with anti-inflammatory and compensatory orexigenic effects. These data contribute to our understanding of the mechanisms underlying the biologic effects of bariatric surgery.",
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AU - O’Rourke, Robert W.

AU - Johnson, Geoffrey S.

AU - Purnell, Jonathan

AU - Courcoulas, Anita P.

AU - Dakin, Gregory F.

AU - Garcia, Luis

AU - Hinojosa, Marcelo

AU - Mitchell, James E.

AU - Pomp, Alfons

AU - Pories, Walter J.

AU - Spaniolas, Konstantinos

AU - Flum, David R.

AU - Wahed, Abdus S.

AU - Wolfe, Bruce

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N2 - Background: The utility of serum biomarkers related to inflammation and adiposity as predictors of metabolic disease prevalence and outcomes after bariatric surgery are not well-defined. Methods: Associations between pre- and post-operative serum levels of four biomarkers (C-reactive protein (CRP), cystatin C (CC), leptin, and ghrelin) with baseline measures of adiposity and metabolic disease prevalence (asthma, diabetes, sleep apnea), and weight loss and metabolic disease remission after bariatric surgery were studied in the Longitudinal Assessment of Bariatric Surgery (LABS) cohort. Results: Baseline CRP levels were positively associated with the odds of asthma but not diabetes or sleep apnea; baseline CC levels were positively associated with asthma, diabetes, and sleep apnea; baseline leptin levels were positively associated with asthma and negatively associated with diabetes and sleep apnea; baseline ghrelin levels were negatively associated with diabetes and sleep apnea. Increased weight loss was associated with increased baseline levels of leptin and CRP and decreased baseline levels of CC. Remission of diabetes and asthma was not associated with baseline levels of any biomarker. A higher likelihood of asthma remission was associated with a greater decrease in leptin levels, and a higher likelihood of diabetes remission was predicted by a lesser decrease in CC. Bariatric surgery was associated with decreased post-operative CC, CRP, and leptin levels, and increased post-operative ghrelin levels. Conclusion: This is the largest study to date of serum biomarkers of inflammation and adiposity in a bariatric surgery cohort. Biomarker levels correlate with metabolic disease prevalence prior to bariatric surgery, and with weight loss but not metabolic disease remission after surgery. Bariatric surgery regulates serum biomarker levels in a manner consistent with anti-inflammatory and compensatory orexigenic effects. These data contribute to our understanding of the mechanisms underlying the biologic effects of bariatric surgery.

AB - Background: The utility of serum biomarkers related to inflammation and adiposity as predictors of metabolic disease prevalence and outcomes after bariatric surgery are not well-defined. Methods: Associations between pre- and post-operative serum levels of four biomarkers (C-reactive protein (CRP), cystatin C (CC), leptin, and ghrelin) with baseline measures of adiposity and metabolic disease prevalence (asthma, diabetes, sleep apnea), and weight loss and metabolic disease remission after bariatric surgery were studied in the Longitudinal Assessment of Bariatric Surgery (LABS) cohort. Results: Baseline CRP levels were positively associated with the odds of asthma but not diabetes or sleep apnea; baseline CC levels were positively associated with asthma, diabetes, and sleep apnea; baseline leptin levels were positively associated with asthma and negatively associated with diabetes and sleep apnea; baseline ghrelin levels were negatively associated with diabetes and sleep apnea. Increased weight loss was associated with increased baseline levels of leptin and CRP and decreased baseline levels of CC. Remission of diabetes and asthma was not associated with baseline levels of any biomarker. A higher likelihood of asthma remission was associated with a greater decrease in leptin levels, and a higher likelihood of diabetes remission was predicted by a lesser decrease in CC. Bariatric surgery was associated with decreased post-operative CC, CRP, and leptin levels, and increased post-operative ghrelin levels. Conclusion: This is the largest study to date of serum biomarkers of inflammation and adiposity in a bariatric surgery cohort. Biomarker levels correlate with metabolic disease prevalence prior to bariatric surgery, and with weight loss but not metabolic disease remission after surgery. Bariatric surgery regulates serum biomarker levels in a manner consistent with anti-inflammatory and compensatory orexigenic effects. These data contribute to our understanding of the mechanisms underlying the biologic effects of bariatric surgery.

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