TY - JOUR
T1 - Serum and dietary vitamin D and cardiovascular disease risk in elderly men
T2 - A prospective cohort study
AU - Messenger, W.
AU - Nielson, C. M.
AU - Li, H.
AU - Beer, T.
AU - Barrett-Connor, E.
AU - Stone, K.
AU - Shannon, J.
N1 - Funding Information:
The Osteoporotic Fractures in Men (MrOS) Study and MrOS Sleep Study is supported by National Institutes of Health funding. The following institutes provide support: the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) , the National Institute of Aging (NIA) , the National Center for Research Resources (NCRR) , NIH Roadmap for Medical Research , and the National Heart, Lung, and Blood Institute (NHLBI) .
PY - 2012/10
Y1 - 2012/10
N2 - Background and aim: Recent research suggests that low vitamin D may be associated with cardiovascular disease (CVD). Methods and results: We prospectively evaluated the association of dietary plus supplemental vitamin D intake and serum 25(OH) vitamin D with CVD incidence in the Osteoporotic Fractures in Men (MrOS) Study. Vitamin D intake was measured using a food frequency questionnaire and self-reported supplemental intake in 3094 men (mean age 76.4 years). From a subset of this population, we measured 25(OH) vitamin D in 813 men. Median 25(OH) vitamin D was 25.3 ng/mL. During a median follow-up of 4.4 years, there were 472 CVD cases, including 371 from coronary heart disease (CHD) and 101 from cerebrovascular attack (CVA). In the 25(OH) vitamin D sub-cohort, there were 140 cases of CVD including 115 from CHD and 25 from CVA. We used a Cox proportional hazards regression to calculate hazard ratios (HR) for CVD by vitamin D quartile. After adjusting for age, season, and standard CVD risk factors, the lowest quartile of 25(OH) vitamin D (HR, 1.18; 95% CI, 0.69-2.03) and vitamin D intake (HR, 0.76; 95% CI, 0.56-1.04) were not significantly associated with CVD incidence, compared to the highest vitamin D quartiles. When 25(OH) vitamin D was further analyzed by sufficiency (≥30 ng/mL), insufficiency (≥15-29.9 ng/mL), and deficiency (<15 ng/mL), vitamin D deficiency was not significantly associated with CVD incidence compared to sufficiency (HR 1.34; 95% CI 0.65-2.77). Conclusion: Vitamin D intake and serum 25(OH) vitamin D were not associated with CVD risk.
AB - Background and aim: Recent research suggests that low vitamin D may be associated with cardiovascular disease (CVD). Methods and results: We prospectively evaluated the association of dietary plus supplemental vitamin D intake and serum 25(OH) vitamin D with CVD incidence in the Osteoporotic Fractures in Men (MrOS) Study. Vitamin D intake was measured using a food frequency questionnaire and self-reported supplemental intake in 3094 men (mean age 76.4 years). From a subset of this population, we measured 25(OH) vitamin D in 813 men. Median 25(OH) vitamin D was 25.3 ng/mL. During a median follow-up of 4.4 years, there were 472 CVD cases, including 371 from coronary heart disease (CHD) and 101 from cerebrovascular attack (CVA). In the 25(OH) vitamin D sub-cohort, there were 140 cases of CVD including 115 from CHD and 25 from CVA. We used a Cox proportional hazards regression to calculate hazard ratios (HR) for CVD by vitamin D quartile. After adjusting for age, season, and standard CVD risk factors, the lowest quartile of 25(OH) vitamin D (HR, 1.18; 95% CI, 0.69-2.03) and vitamin D intake (HR, 0.76; 95% CI, 0.56-1.04) were not significantly associated with CVD incidence, compared to the highest vitamin D quartiles. When 25(OH) vitamin D was further analyzed by sufficiency (≥30 ng/mL), insufficiency (≥15-29.9 ng/mL), and deficiency (<15 ng/mL), vitamin D deficiency was not significantly associated with CVD incidence compared to sufficiency (HR 1.34; 95% CI 0.65-2.77). Conclusion: Vitamin D intake and serum 25(OH) vitamin D were not associated with CVD risk.
KW - Cardiovascular disease
KW - Epidemiology
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=84857263339&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857263339&partnerID=8YFLogxK
U2 - 10.1016/j.numecd.2010.10.019
DO - 10.1016/j.numecd.2010.10.019
M3 - Article
C2 - 21466949
AN - SCOPUS:84857263339
SN - 0939-4753
VL - 22
SP - 856
EP - 863
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
IS - 10
ER -