Serum 25-OH vitamin D levels and risk of developing prostate cancer in older men

Christine M. Barnett, Carrie M. Nielson, Jackie Shannon, June M. Chan, James M. Shikany, Douglas C. Bauer, Andrew R. Hoffman, Elizabeth Barrett-Connor, Eric Orwoll, Tomasz M. Beer

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Objective: Multiple studies have shown clear evidence of vitamin D's anti-tumor effects on prostate cancer cells in laboratory experiments, but the evidence has not been consistent in humans. We sought to examine the association between vitamin D and prostate cancer risk in a cohort of older men. Methods: We conducted a prospective case-cohort study nested within the multicenter Osteoporotic Fractures in Men (MrOS) study. Baseline serum 25-OH vitamin D was measured in a randomly selected sub-cohort of 1,433 men ≥ 65 years old without a history of prostate cancer and from all participants with an incident diagnosis of prostate cancer (n = 297). Cox proportional hazards models were used to evaluate the associations between quartiles of total 25-OH vitamin D and incident prostate cancer, as well as Gleason score. Results: In comparison with the lowest quartile of 25-OH vitamin D, the hazard ratio for the highest quartile of 25-OH vitamin D was 1.22 (CI 0.50-1.72, p = 0.25), no trend across quartiles (p = 0.94) or association with Gleason score was observed. Adjustment for covariates did not alter the results. Conclusions: In this prospective cohort of older men, we found no association between serum 25-OH vitamin D levels and subsequent risk of prostate cancer.

Original languageEnglish (US)
Pages (from-to)1297-1303
Number of pages7
JournalCancer Causes and Control
Volume21
Issue number8
DOIs
StatePublished - Aug 1 2010

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Keywords

  • Prostate cancer
  • Vitamin D

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Barnett, C. M., Nielson, C. M., Shannon, J., Chan, J. M., Shikany, J. M., Bauer, D. C., Hoffman, A. R., Barrett-Connor, E., Orwoll, E., & Beer, T. M. (2010). Serum 25-OH vitamin D levels and risk of developing prostate cancer in older men. Cancer Causes and Control, 21(8), 1297-1303. https://doi.org/10.1007/s10552-010-9557-y