Serum 25-hydroxyvitamin D levels and rate of hip bone loss in older men

Kristine E. Ensrud, Brent C. Taylor, Misti L. Paudel, Jane A. Cauley, Peggy M. Cawthon, Steven R. Cummings, Howard A. Fink, Elizabeth Barrett-Connor, Joseph M. Zmuda, James M. Shikany, Eric Orwoll

Research output: Contribution to journalArticle

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Abstract

Context: Vitamin D deficiency is common among older adults, but the association between 25-hydroxyvitamin D [25(OH)D] levels and rates of bone loss is uncertain. Objective: Our aim was to test the hypothesis that lower 25(OH)D levels are associated with higher rates of hip bone loss in older men. Design and Setting: We conducted a prospective cohort study in six U.S. centers. Participants: A total of 1279 community-dwelling men aged 65 yr or older with 25(OH)D levels (liquid chromatography-tandem mass spectroscopy) and hip bone mineral density (BMD) (dual-energy x-ray absorptiometry) at baseline and repeat hip BMD an average of 4.4 yr later participated in the study. Main Outcome Measure(s): We measured the annualized percentage rate of change in hip BMD. Results: After adjustment for multiple potential confounders, the average rate of decline in total hip BMD was -0.59%/yr among men with 25(OH)D levels below 15.0 ng/ml, -0.54%/yr among men with 25(OH)D levels 15.0-19.9 ng/ml, -0.35%/yr among men with 25(OH)D levels 20.0-29.9 ng/ml, and -0.37%/yr among men with 25(OH)D levels of at least 30 ng/ml (P trend = 0.008 for multi-variable model). Evidence was strong to support an association among men aged 75 yr and older (P trend

Original languageEnglish (US)
Pages (from-to)2773-2780
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume94
Issue number8
DOIs
StatePublished - Aug 2009

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Pelvic Bones
Bone
Minerals
Bone Density
Serum
Association reactions
Independent Living
Liquid chromatography
Vitamin D Deficiency
Vitamin D
25-hydroxyvitamin D
Liquid Chromatography
Mass Spectrometry
Spectroscopy
Cohort Studies
X rays
X-Rays
Outcome Assessment (Health Care)
Prospective Studies
Bone and Bones

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Ensrud, K. E., Taylor, B. C., Paudel, M. L., Cauley, J. A., Cawthon, P. M., Cummings, S. R., ... Orwoll, E. (2009). Serum 25-hydroxyvitamin D levels and rate of hip bone loss in older men. Journal of Clinical Endocrinology and Metabolism, 94(8), 2773-2780. https://doi.org/10.1210/jc.2008-2786

Serum 25-hydroxyvitamin D levels and rate of hip bone loss in older men. / Ensrud, Kristine E.; Taylor, Brent C.; Paudel, Misti L.; Cauley, Jane A.; Cawthon, Peggy M.; Cummings, Steven R.; Fink, Howard A.; Barrett-Connor, Elizabeth; Zmuda, Joseph M.; Shikany, James M.; Orwoll, Eric.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 8, 08.2009, p. 2773-2780.

Research output: Contribution to journalArticle

Ensrud, KE, Taylor, BC, Paudel, ML, Cauley, JA, Cawthon, PM, Cummings, SR, Fink, HA, Barrett-Connor, E, Zmuda, JM, Shikany, JM & Orwoll, E 2009, 'Serum 25-hydroxyvitamin D levels and rate of hip bone loss in older men', Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 8, pp. 2773-2780. https://doi.org/10.1210/jc.2008-2786
Ensrud KE, Taylor BC, Paudel ML, Cauley JA, Cawthon PM, Cummings SR et al. Serum 25-hydroxyvitamin D levels and rate of hip bone loss in older men. Journal of Clinical Endocrinology and Metabolism. 2009 Aug;94(8):2773-2780. https://doi.org/10.1210/jc.2008-2786
Ensrud, Kristine E. ; Taylor, Brent C. ; Paudel, Misti L. ; Cauley, Jane A. ; Cawthon, Peggy M. ; Cummings, Steven R. ; Fink, Howard A. ; Barrett-Connor, Elizabeth ; Zmuda, Joseph M. ; Shikany, James M. ; Orwoll, Eric. / Serum 25-hydroxyvitamin D levels and rate of hip bone loss in older men. In: Journal of Clinical Endocrinology and Metabolism. 2009 ; Vol. 94, No. 8. pp. 2773-2780.
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