Abstract
L-5-hydroxytryptophan (5-HTP) - induced GH release has been demonstrated in animals and man, but serotoninergic control remains controversial. We developed a sensitive radioimmuno-assay for measurement of canine GH and investigated the 5-HTP dose-response relationship in unanesthetized mongrel bitches. Intravenous administration of 1, 5, 10, and 25 mg/kg doses of 5-HTP caused GH release but an increased latency in peak GH response was seen with the larger doses. Doses of 10 and 25 mg/kg induced stressful behavior and markedly increased plasma corticoid levels while lower doses were without effect. From these findings in the dog we conclude that the GH response to low dose 5-HTP is not due to stress and that alternate mechanisms are needed to explain the variable serotoninergic control of GH release demonstrated with low and high dose 5-HTP stimulation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1391-1398 |
| Number of pages | 8 |
| Journal | Life Sciences |
| Volume | 22 |
| Issue number | 16 |
| DOIs | |
| State | Published - Apr 24 1978 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Serotoninergic control of growth hormone (GH) secretion in dogs as measured by dose responsiveness. / Dorsa, Daniel; Connors, Matthew H.
In: Life Sciences, Vol. 22, No. 16, 24.04.1978, p. 1391-1398.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serotoninergic control of growth hormone (GH) secretion in dogs as measured by dose responsiveness
AU - Dorsa, Daniel
AU - Connors, Matthew H.
PY - 1978/4/24
Y1 - 1978/4/24
N2 - L-5-hydroxytryptophan (5-HTP) - induced GH release has been demonstrated in animals and man, but serotoninergic control remains controversial. We developed a sensitive radioimmuno-assay for measurement of canine GH and investigated the 5-HTP dose-response relationship in unanesthetized mongrel bitches. Intravenous administration of 1, 5, 10, and 25 mg/kg doses of 5-HTP caused GH release but an increased latency in peak GH response was seen with the larger doses. Doses of 10 and 25 mg/kg induced stressful behavior and markedly increased plasma corticoid levels while lower doses were without effect. From these findings in the dog we conclude that the GH response to low dose 5-HTP is not due to stress and that alternate mechanisms are needed to explain the variable serotoninergic control of GH release demonstrated with low and high dose 5-HTP stimulation.
AB - L-5-hydroxytryptophan (5-HTP) - induced GH release has been demonstrated in animals and man, but serotoninergic control remains controversial. We developed a sensitive radioimmuno-assay for measurement of canine GH and investigated the 5-HTP dose-response relationship in unanesthetized mongrel bitches. Intravenous administration of 1, 5, 10, and 25 mg/kg doses of 5-HTP caused GH release but an increased latency in peak GH response was seen with the larger doses. Doses of 10 and 25 mg/kg induced stressful behavior and markedly increased plasma corticoid levels while lower doses were without effect. From these findings in the dog we conclude that the GH response to low dose 5-HTP is not due to stress and that alternate mechanisms are needed to explain the variable serotoninergic control of GH release demonstrated with low and high dose 5-HTP stimulation.
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U2 - 10.1016/0024-3205(78)90632-X
DO - 10.1016/0024-3205(78)90632-X
M3 - Article
VL - 22
SP - 1391
EP - 1398
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 16
ER -