Serotonergic stimulation of prolactin and corticosterone secretion is mediated by different pathways from the mediobasal hypothalamus

Louis D. Van De Kar, Mihaly Karteszi, Cynthia L. Bethea, William F. Ganong

    Research output: Contribution to journalArticle

    71 Scopus citations

    Abstract

    In previous studies we obtained evidence that serotonin release by β-chloroamphetamine (PCA) causes an increase in corticosterone secretion but that this effect is not mediated via the raphe nuclei in the midbrain. In contrast. PCA-induced prolactin secretion was abolished by dorsal raphe lesions. In the present study, posterolateral cuts which interrupted caudal inputs to the hypothalamus attenuated the cffcct of PCA on plasma prolactin but did not block the PCA-induced increase in plasma corticosterone levels. Large lesions of the mediobasal hypothalamus produced a significant reduction of plasma corticosterone concentration but did not completely prevent the effect of PCA on corticosterone secretion. Hypophysectomy performed 24 h before sacrifice caused a marked decrease in plasma corticosterone levels but did not completely abolish the effect of PCA. These results suggest that PCA also stimulates corticosterone secretion via a direct action on the adrenal gland. The lesions in the mediobasal hypothalamus caused an increase in plasma prolactin concentration, and in these rats, PCA suppressed rather than stimulated prolactin secretion. This suggests that the known weak dopamine agonist activity of PCA is exposed when the effects of serotonin release in the brain are eliminated.

    Original languageEnglish (US)
    Pages (from-to)380-384
    Number of pages5
    JournalNeuroendocrinology
    Volume41
    Issue number5
    DOIs
    StatePublished - Jan 1 1985

    Keywords

    • Corticosterone secretion
    • Hypothalamus
    • Prolactin secretion
    • Serotonergic pathways
    • Serotonin

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology
    • Endocrine and Autonomic Systems
    • Cellular and Molecular Neuroscience

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