Serine/threonine protein kinases

John D. Scott, Thomas R. Soderling

    Research output: Contribution to journalArticlepeer-review

    27 Scopus citations

    Abstract

    Signal transduction in the nervous system is heavily dependent on the three multifunctional serine/threonine protein kinases, PKA, PKC, and CaM-KII. Recent studies have furthered our understanding of how the multiple isoforms of these kinases and their subcellular localizations, regulatory properties, and substrate determinants are important for the specificity of kinase functions.

    Original languageEnglish (US)
    Pages (from-to)289-295
    Number of pages7
    JournalCurrent Opinion in Neurobiology
    Volume2
    Issue number3
    DOIs
    StatePublished - Jun 1992

    Keywords

    • C-catalytic
    • CREB-cAMP-response-element binding protein
    • CaM-KII-Ca/calmodulin-dependent protein kinase II
    • DAG-diacylglycerol
    • IP-inositol 1,4,5-trisphosp hate
    • LTP-long-term potentiation
    • MAP-2-microtubule-associated protein 2
    • NMDA-N-methyl-D-aspartate
    • PKA-protein kinase A
    • PKC-protein kinase C
    • R-regulatory

    ASJC Scopus subject areas

    • Neuroscience(all)

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