Serine/threonine protein kinases

John D. Scott, Thomas R. Soderling

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Signal transduction in the nervous system is heavily dependent on the three multifunctional serine/threonine protein kinases, PKA, PKC, and CaM-KII. Recent studies have furthered our understanding of how the multiple isoforms of these kinases and their subcellular localizations, regulatory properties, and substrate determinants are important for the specificity of kinase functions.

Original languageEnglish (US)
Pages (from-to)289-295
Number of pages7
JournalCurrent Opinion in Neurobiology
Issue number3
StatePublished - Jun 1992


  • C-catalytic
  • CREB-cAMP-response-element binding protein
  • CaM-KII-Ca/calmodulin-dependent protein kinase II
  • DAG-diacylglycerol
  • IP-inositol 1,4,5-trisphosp hate
  • LTP-long-term potentiation
  • MAP-2-microtubule-associated protein 2
  • NMDA-N-methyl-D-aspartate
  • PKA-protein kinase A
  • PKC-protein kinase C
  • R-regulatory

ASJC Scopus subject areas

  • Neuroscience(all)


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