Abstract
Signal transduction in the nervous system is heavily dependent on the three multifunctional serine/threonine protein kinases, PKA, PKC, and CaM-KII. Recent studies have furthered our understanding of how the multiple isoforms of these kinases and their subcellular localizations, regulatory properties, and substrate determinants are important for the specificity of kinase functions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 289-295 |
| Number of pages | 7 |
| Journal | Current Opinion in Neurobiology |
| Volume | 2 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 1992 |
Keywords
- C-catalytic
- CREB-cAMP-response-element binding protein
- CaM-KII-Ca/calmodulin-dependent protein kinase II
- DAG-diacylglycerol
- IP-inositol 1,4,5-trisphosp hate
- LTP-long-term potentiation
- MAP-2-microtubule-associated protein 2
- NMDA-N-methyl-D-aspartate
- PKA-protein kinase A
- PKC-protein kinase C
- R-regulatory
ASJC Scopus subject areas
- Neuroscience(all)