TY - JOUR
T1 - Serial Transthoracic Ultrasonography Studies in Hematopoietic Cell Transplant Patients
T2 - A Tool for Early Lung Pathology Detection
AU - Zhu, Meihua
AU - Gregory, Cynthia R.
AU - Hayes-Lattin, Brandon
AU - Jacoby, Carol
AU - Zhang, Xijun
AU - Halse, Amber
AU - Wang, Fen
AU - Gregory, Kenton W.
AU - Maziarz, Richard T.
N1 - Publisher Copyright:
© 2022 World Federation for Ultrasound in Medicine & Biology
PY - 2023/1
Y1 - 2023/1
N2 - Early detection of pulmonary complications can improve outcomes for patients with hematological malignancy (HM). For detecting lung injuries, lung ultrasound (LUS) images have been found to be of greater sensitivity than radiographic images. Our group performed a pilot study of LUS imaging to enhance early detection of pulmonary complications in HM patients. This prospective single-center feasibility study evaluated LUS for detecting pulmonary complications in 18 HM patients enrolled while hospitalized for a hematopoietic cell transplant (HCT) (concurrent-HCT group) or re-hospitalized for complications (post-HCT group). Serial LUS exams were performed and assigned a score from 0 to 5 based on pleural line, B-line, consolidation and pleural effusion features. Correlations between patients’ clinical characteristics and LUS features were analyzed. Comparisons between the LUS and radiographic images were evaluated. In the concurrent-HCT patients (79 LUS exams), non-significant fluctuating findings were commonly identified, but one-third of the patients presented pathologic findings (LUS scores ≥ 3). In the post-HCT patients (29 LUS exams), LUS images revealed severe pathologic findings (LUS score = 5) in every patient and, compared with radiographic images, were more sensitive for detecting pleural effusions (p < 0.05). LUS can be routinely performed on hospitalized HM patients, allowing point-of-care early detection of pulmonary complications.
AB - Early detection of pulmonary complications can improve outcomes for patients with hematological malignancy (HM). For detecting lung injuries, lung ultrasound (LUS) images have been found to be of greater sensitivity than radiographic images. Our group performed a pilot study of LUS imaging to enhance early detection of pulmonary complications in HM patients. This prospective single-center feasibility study evaluated LUS for detecting pulmonary complications in 18 HM patients enrolled while hospitalized for a hematopoietic cell transplant (HCT) (concurrent-HCT group) or re-hospitalized for complications (post-HCT group). Serial LUS exams were performed and assigned a score from 0 to 5 based on pleural line, B-line, consolidation and pleural effusion features. Correlations between patients’ clinical characteristics and LUS features were analyzed. Comparisons between the LUS and radiographic images were evaluated. In the concurrent-HCT patients (79 LUS exams), non-significant fluctuating findings were commonly identified, but one-third of the patients presented pathologic findings (LUS scores ≥ 3). In the post-HCT patients (29 LUS exams), LUS images revealed severe pathologic findings (LUS score = 5) in every patient and, compared with radiographic images, were more sensitive for detecting pleural effusions (p < 0.05). LUS can be routinely performed on hospitalized HM patients, allowing point-of-care early detection of pulmonary complications.
KW - Hematologic malignancies
KW - Hematopoietic cell transplant
KW - Lung injury
KW - Lung ultrasound
KW - Pulmonary complications
UR - http://www.scopus.com/inward/record.url?scp=85140791455&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85140791455&partnerID=8YFLogxK
U2 - 10.1016/j.ultrasmedbio.2022.08.002
DO - 10.1016/j.ultrasmedbio.2022.08.002
M3 - Article
C2 - 36216657
AN - SCOPUS:85140791455
SN - 0301-5629
VL - 49
SP - 72
EP - 89
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 1
ER -