Serial quantitative ct analysis of brain morphometrics in adult down’s syndrome at different ages

M. B. Schapiro, J. S. Luxenberg, J. A. Kaye, J. V. Haxby, R. P. Friedland, S. I. Rapoport

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Quantitative CT demonstrated increased CSF and 3rd ventricular volumes, and decreased gray matter and white matter volume, in older (>45 years) Down’s syndrome (DS) adults with dementia as compared with younger DS adults. Serial CT studies repeated after periods of up to 2 years demonstrated significant progressive cerebral atrophy. Older DS adults without dementia, but with cognitive decline, did not show cerebral atrophy as compared with young DS subjects. These results suggest brain atrophy must be present to accompany dementia in older DS subjects, despite the presence of Alzheimer’s disease neuropathology in all older subjects. The Alzheimer’s disease process in DS may occur in 2 stages, the 1st with neuropathology and cognitive decline, the 2nd with additional cerebral atrophy and dementia.

Original languageEnglish (US)
Pages (from-to)1349-1353
Number of pages5
JournalNeurology
Volume39
Issue number10
DOIs
StatePublished - Oct 1989

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Serial quantitative ct analysis of brain morphometrics in adult down’s syndrome at different ages'. Together they form a unique fingerprint.

  • Cite this

    Schapiro, M. B., Luxenberg, J. S., Kaye, J. A., Haxby, J. V., Friedland, R. P., & Rapoport, S. I. (1989). Serial quantitative ct analysis of brain morphometrics in adult down’s syndrome at different ages. Neurology, 39(10), 1349-1353. https://doi.org/10.1212/wnl.39.10.1349