Serial quantitative ct analysis of brain morphometrics in adult down’s syndrome at different ages

M. B. Schapiro, J. S. Luxenberg, Jeffrey Kaye, J. V. Haxby, R. P. Friedland, S. I. Rapoport

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Quantitative CT demonstrated increased CSF and 3rd ventricular volumes, and decreased gray matter and white matter volume, in older (>45 years) Down’s syndrome (DS) adults with dementia as compared with younger DS adults. Serial CT studies repeated after periods of up to 2 years demonstrated significant progressive cerebral atrophy. Older DS adults without dementia, but with cognitive decline, did not show cerebral atrophy as compared with young DS subjects. These results suggest brain atrophy must be present to accompany dementia in older DS subjects, despite the presence of Alzheimer’s disease neuropathology in all older subjects. The Alzheimer’s disease process in DS may occur in 2 stages, the 1st with neuropathology and cognitive decline, the 2nd with additional cerebral atrophy and dementia.

Original languageEnglish (US)
Pages (from-to)1349-1353
Number of pages5
JournalNeurology
Volume39
Issue number10
StatePublished - 1989
Externally publishedYes

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Down Syndrome
Atrophy
Dementia
Brain
Alzheimer Disease
Morphometrics
Quantitative Analysis

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Schapiro, M. B., Luxenberg, J. S., Kaye, J., Haxby, J. V., Friedland, R. P., & Rapoport, S. I. (1989). Serial quantitative ct analysis of brain morphometrics in adult down’s syndrome at different ages. Neurology, 39(10), 1349-1353.

Serial quantitative ct analysis of brain morphometrics in adult down’s syndrome at different ages. / Schapiro, M. B.; Luxenberg, J. S.; Kaye, Jeffrey; Haxby, J. V.; Friedland, R. P.; Rapoport, S. I.

In: Neurology, Vol. 39, No. 10, 1989, p. 1349-1353.

Research output: Contribution to journalArticle

Schapiro, MB, Luxenberg, JS, Kaye, J, Haxby, JV, Friedland, RP & Rapoport, SI 1989, 'Serial quantitative ct analysis of brain morphometrics in adult down’s syndrome at different ages', Neurology, vol. 39, no. 10, pp. 1349-1353.
Schapiro MB, Luxenberg JS, Kaye J, Haxby JV, Friedland RP, Rapoport SI. Serial quantitative ct analysis of brain morphometrics in adult down’s syndrome at different ages. Neurology. 1989;39(10):1349-1353.
Schapiro, M. B. ; Luxenberg, J. S. ; Kaye, Jeffrey ; Haxby, J. V. ; Friedland, R. P. ; Rapoport, S. I. / Serial quantitative ct analysis of brain morphometrics in adult down’s syndrome at different ages. In: Neurology. 1989 ; Vol. 39, No. 10. pp. 1349-1353.
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