TY - JOUR
T1 - Serial left ventricular wall measurements in Duchenne's muscular dystrophy
AU - Goldberg, Stanley J.
AU - Stern, Lawrence Z.
AU - Feldman, Linda
AU - Sahn, David J.
AU - Allen, Hugh D.
AU - Valdes-Cruz, Lilliam M.
N1 - Funding Information:
From the Departments of Pediatrics (Cardiology) and Internal Medicine (Neurology), University of Arizona, Health SCiences Center, Tucson, Arizona. This work was supported in part by a grant from the Muscular Dystrophy Association, Inc., New York, New York. Manuscript received July 14, 1982; revised manuscript received December 20, 1982, accepted December 23, 1982.
PY - 1983
Y1 - 1983
N2 - In 19 patients with Duchenne's muscular dystrophy, left ventricular wall thickness in end-systole and end-diastole was determined serially every 12 months by echocardiography and compared with ventricular wall growth in normal subjects. In the normal subjects, left ventricular wall thickness increased linearly with increasing body surface area. A control group of wheelchair-bound patients with a variety of neurologic disorders, although not followed serially, had a distribution of end-diastolic wall thickness values similar to that of the normal subjects. In patients with muscular dystrophy, wall thickness increased linearly with respect to body surface area for some time and then began to thin. The time at which thinning began was not directly related to age, although it was more common in older than in younger patients. Those patients who died demonstrated marked deviation from normal wall growth. Free wall thinning is probably a result of fibrosis and loss of myofibrils.
AB - In 19 patients with Duchenne's muscular dystrophy, left ventricular wall thickness in end-systole and end-diastole was determined serially every 12 months by echocardiography and compared with ventricular wall growth in normal subjects. In the normal subjects, left ventricular wall thickness increased linearly with increasing body surface area. A control group of wheelchair-bound patients with a variety of neurologic disorders, although not followed serially, had a distribution of end-diastolic wall thickness values similar to that of the normal subjects. In patients with muscular dystrophy, wall thickness increased linearly with respect to body surface area for some time and then began to thin. The time at which thinning began was not directly related to age, although it was more common in older than in younger patients. Those patients who died demonstrated marked deviation from normal wall growth. Free wall thinning is probably a result of fibrosis and loss of myofibrils.
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U2 - 10.1016/S0735-1097(83)80386-6
DO - 10.1016/S0735-1097(83)80386-6
M3 - Article
C2 - 6853908
AN - SCOPUS:0020560483
SN - 0735-1097
VL - 2
SP - 136
EP - 142
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 1
ER -