Abstract
Septic shock and the formation of pulmonary edema were studied in 19 baboons. Four animals served as controls. Four were subjected to deep septic shock by infusion of live E. coli and then deliberately killed while in deep shock. Four were subjected to septic shock, resuscitated with Ringer’s lactate (RL), and then killed 1½ hours after resuscitation was started. Seven were subjected to shock and resuscitation attempted with Plasmanate (PL). Resuscitation with RL was successful for 1½ hours in all four RL-animals. Resuscitation with PL was successful for 1½ hours in three of the 7 PL-animals. There was an increased tendency for albumin to extravasate into the interstitium of the lungs after resuscitation. The amount of pulmonary edema, measured by both the thermodye technique and by analysis of post-mortem lung composition, was the same in animals resuscitated with RL and PL. Administration of pure colloid offers no protection to the lungs in resuscitating patients from septic shock.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 600-610 |
| Number of pages | 11 |
| Journal | Journal of Trauma - Injury, Infection and Critical Care |
| Volume | 17 |
| Issue number | 8 |
| State | Published - 1977 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
- Surgery
Cite this
Sepsis in the baboon : Factors affecting resuscitation and pulmonary edema in animals resuscitated with ringer’s lactate versus plasmanate. / Holcroft, James W.; Trunkey, Donald; Carpenter, Mary Ann.
In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 17, No. 8, 1977, p. 600-610.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sepsis in the baboon
T2 - Factors affecting resuscitation and pulmonary edema in animals resuscitated with ringer’s lactate versus plasmanate
AU - Holcroft, James W.
AU - Trunkey, Donald
AU - Carpenter, Mary Ann
PY - 1977
Y1 - 1977
N2 - Septic shock and the formation of pulmonary edema were studied in 19 baboons. Four animals served as controls. Four were subjected to deep septic shock by infusion of live E. coli and then deliberately killed while in deep shock. Four were subjected to septic shock, resuscitated with Ringer’s lactate (RL), and then killed 1½ hours after resuscitation was started. Seven were subjected to shock and resuscitation attempted with Plasmanate (PL). Resuscitation with RL was successful for 1½ hours in all four RL-animals. Resuscitation with PL was successful for 1½ hours in three of the 7 PL-animals. There was an increased tendency for albumin to extravasate into the interstitium of the lungs after resuscitation. The amount of pulmonary edema, measured by both the thermodye technique and by analysis of post-mortem lung composition, was the same in animals resuscitated with RL and PL. Administration of pure colloid offers no protection to the lungs in resuscitating patients from septic shock.
AB - Septic shock and the formation of pulmonary edema were studied in 19 baboons. Four animals served as controls. Four were subjected to deep septic shock by infusion of live E. coli and then deliberately killed while in deep shock. Four were subjected to septic shock, resuscitated with Ringer’s lactate (RL), and then killed 1½ hours after resuscitation was started. Seven were subjected to shock and resuscitation attempted with Plasmanate (PL). Resuscitation with RL was successful for 1½ hours in all four RL-animals. Resuscitation with PL was successful for 1½ hours in three of the 7 PL-animals. There was an increased tendency for albumin to extravasate into the interstitium of the lungs after resuscitation. The amount of pulmonary edema, measured by both the thermodye technique and by analysis of post-mortem lung composition, was the same in animals resuscitated with RL and PL. Administration of pure colloid offers no protection to the lungs in resuscitating patients from septic shock.
UR - http://www.scopus.com/inward/record.url?scp=0017740019&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017740019&partnerID=8YFLogxK
M3 - Article
VL - 17
SP - 600
EP - 610
JO - Journal of Trauma and Acute Care Surgery
JF - Journal of Trauma and Acute Care Surgery
SN - 2163-0755
IS - 8
ER -