Sensory contributions to impaired emotion processing in schizophrenia

Pamela D. Butler, Ilana Y. Abeles, Nicole Weiskopf, Arielle Tambini, Maria Jalbrzikowski, Michael E. Legatt, Vance Zemon, James Loughead, Ruben C. Gur, Daniel C. Javitt

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Both emotion and visual processing deficits are documented in schizophrenia, and preferential magnocellular visual pathway dysfunction has been reported in several studies. This study examined the contribution to emotion-processing deficits of magnocellular and parvocellular visual pathway function, based on stimulus properties and shape of contrast response functions. Experiment 1 examined the relationship between contrast sensitivity to magnocellular- and parvocellular-biased stimuli and emotion recognition using the Penn Emotion Recognition (ER-40) and Emotion Differentiation (EMODIFF) tests. Experiment 2 altered the contrast levels of the faces themselves to determine whether emotion detection curves would show a pattern characteristic of magnocellular neurons and whether patients would show a deficit in performance related to early sensory processing stages. Results for experiment 1 showed that patients had impaired emotion processing and a preferential magnocellular deficit on the contrast sensitivity task. Greater deficits in ER-40 and EMODIFF performance correlated with impaired contrast sensitivity to the magnocellular-biased condition, which remained significant for the EMODIFF task even when nonspecific correlations due to group were considered in a step-wise regression. Experiment 2 showed contrast response functions indicative of magnocellular processing for both groups, with patients showing impaired performance. Impaired emotion identification on this task was also correlated with magnocellular-biased visual sensory processing dysfunction. These results provide evidence for a contribution of impaired early-stage visual processing in emotion recognition deficits in schizophrenia and suggest that a bottom-up approach to remediation may be effective.

Original languageEnglish (US)
Pages (from-to)1095-1107
Number of pages13
JournalSchizophrenia Bulletin
Volume35
Issue number6
DOIs
StatePublished - Nov 2009
Externally publishedYes

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Schizophrenia
Emotions
Contrast Sensitivity
Visual Pathways
Neurons

Keywords

  • contrast
  • gain control
  • magnocellular
  • spatial frequency
  • visual

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Butler, P. D., Abeles, I. Y., Weiskopf, N., Tambini, A., Jalbrzikowski, M., Legatt, M. E., ... Javitt, D. C. (2009). Sensory contributions to impaired emotion processing in schizophrenia. Schizophrenia Bulletin, 35(6), 1095-1107. https://doi.org/10.1093/schbul/sbp109

Sensory contributions to impaired emotion processing in schizophrenia. / Butler, Pamela D.; Abeles, Ilana Y.; Weiskopf, Nicole; Tambini, Arielle; Jalbrzikowski, Maria; Legatt, Michael E.; Zemon, Vance; Loughead, James; Gur, Ruben C.; Javitt, Daniel C.

In: Schizophrenia Bulletin, Vol. 35, No. 6, 11.2009, p. 1095-1107.

Research output: Contribution to journalArticle

Butler, PD, Abeles, IY, Weiskopf, N, Tambini, A, Jalbrzikowski, M, Legatt, ME, Zemon, V, Loughead, J, Gur, RC & Javitt, DC 2009, 'Sensory contributions to impaired emotion processing in schizophrenia', Schizophrenia Bulletin, vol. 35, no. 6, pp. 1095-1107. https://doi.org/10.1093/schbul/sbp109
Butler PD, Abeles IY, Weiskopf N, Tambini A, Jalbrzikowski M, Legatt ME et al. Sensory contributions to impaired emotion processing in schizophrenia. Schizophrenia Bulletin. 2009 Nov;35(6):1095-1107. https://doi.org/10.1093/schbul/sbp109
Butler, Pamela D. ; Abeles, Ilana Y. ; Weiskopf, Nicole ; Tambini, Arielle ; Jalbrzikowski, Maria ; Legatt, Michael E. ; Zemon, Vance ; Loughead, James ; Gur, Ruben C. ; Javitt, Daniel C. / Sensory contributions to impaired emotion processing in schizophrenia. In: Schizophrenia Bulletin. 2009 ; Vol. 35, No. 6. pp. 1095-1107.
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