Sensory afferent neurotransmission in caudal nucleus tractus solitarius - Common denominators

Michael Andresen, David Mendelowitz

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The nucleus of the solitary tract (NTS) receives a wide range of sensory inputs including gustatory, gastrointestinal and cardiorespiratory which are loosely segregated viscerotopically to subnuclei. Our laboratory has focused on a dorsomedial area of caudal NTS (mNTS) which is critical for cardiovascular reflexes. Using a brainslice, we study primarily mNTS neurons mono-synaptically activated by solitary tract stimulation. mNTS neurons show varying degrees of delayed excitation, spike frequency adaptation and after hyperpolarizations. Sensory afferent transmission is mediated by glutamate acting at post-synaptic non-NMDA receptors. Glutamate release depends on at least four different presynaptic calcium channels with N-type predominating. This profile of presynaptic calcium channels in NTS is also present at the peripheral soma, but absent from the baroreceptor sensory endings. Many peptides are associated with these sensory neurons and several modulate glutamatergic transmission in mNTS. Angiotensin II facilitates excitatory responses to sensory afferent activation by a presynaptic mechanism. Caudal NTS appears to have a framework of synaptic and cellular mechanisms in common with other NTS areas and peptides may play a critical role modulating this framework.

Original languageEnglish (US)
Pages (from-to)387-395
Number of pages9
JournalChemical Senses
Volume21
Issue number3
DOIs
StatePublished - Jun 1996

Fingerprint

Solitary Nucleus
calcium channels
Synaptic Transmission
glutamates
Glutamic Acid
neurons
N-Type Calcium Channels
peptides
Neurons
Peptides
Pressoreceptors
angiotensin II
sensory neurons
Carisoprodol
Sensory Receptor Cells
Calcium Channels
reflexes
Angiotensin II
Reflex
receptors

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Neuroscience(all)
  • Physiology
  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Sensory afferent neurotransmission in caudal nucleus tractus solitarius - Common denominators. / Andresen, Michael; Mendelowitz, David.

In: Chemical Senses, Vol. 21, No. 3, 06.1996, p. 387-395.

Research output: Contribution to journalArticle

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