Abstract
Mice genetically selected to be resistant (withdrawal-seizure resistant, WSR) or prone (withdrawal-seizure prone, WSP) to handling-induced convulsions during ethanol withdrawal were tested for sensitivity to convulsions induced by timed intravenous (i.v.) infusion of N-methyl- d-aspartic acid (NMDA). WSR mice displayed convulsions at infused doses of NMDA that averaged 20% lower than WSP mice. This result was present in both genetically independent replicates of the WSR and WSP mice and provides strong evidence for an involvelment of the NMDA system in the difference in withdrawal seizures present in these lines.
Original language | English (US) |
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Pages (from-to) | 176-179 |
Number of pages | 4 |
Journal | Brain research |
Volume | 610 |
Issue number | 1 |
DOIs | |
State | Published - Apr 30 1993 |
Externally published | Yes |
Keywords
- Behavior genetics
- Convulsion
- Ethanol
- Ethanol withdrawal
- N-Methyl-d-aspartic acid
- Pharmacogenetics
- Selected mouse line
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology