Sensitivity of petrolatum and aqueous vehicles for detecting allergy to imidazolidinylurea, diazolidinylurea, and DMDM hydantoin: A retrospective analysis from the North American contact dermatitis group

Robert L. Rietschel, Erin M. Warshaw, Denis Sasseville, Joseph F. Fowler, Vincent A. DeLeo, Donald V. Belsito, James S. Taylor, Frances Storrs, C. G Toby Mathias, Howard I. Maibach, James G. Marks, Kathryn A. Zug, Melanie Pratt

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: To determine whether petrolatum or aqueous vehicles are more sensitive for detecting allergy to imidazolidinylurea (IU), diazolidinylurea (DU), and dimethylol dimethyl hydantoin (DM). The relationship of these allergens to formaldehyde sensitivity was also explored. Methods: Retrospective analysis of patients patch-tested by the North American Contact Dermatitis Group. All patients were simultaneously tested to seven allergens (formaldehyde, IU in petrolatum [pet], IU aqueous [aq], DU pet, DU aq, DM pet, and DM aq). Data were analyzed in pairs with various "gold standard" definitions of "true allergy" and adjusting for correlated data. Results: Reaction to at least one of the seven allergens occurred in 2,398 patients. In all cases except one (which just approached statistical significance), the petrolatum-based allergen was statistically significantly more sensitive than the same allergen in an aqueous base. Most of the patients allergic to the three preservatives were also allergic to formaldehyde, but most formaldehyde- allergic patients were not allergic to the IU, DU, or DM. Conclusion: Of these two vehicles, petrolatum is significantly more sensitive than an aqueous vehicle is for detecting allergy to IU, DU, and DM.

Original languageEnglish (US)
Pages (from-to)155-162
Number of pages8
JournalDermatitis
Volume18
Issue number3
DOIs
StatePublished - Sep 2007
Externally publishedYes

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Petrolatum
Hydantoins
Contact Dermatitis
Hypersensitivity
Allergens
Formaldehyde
1,3-dimethylol-5,5-dimethylhydantoin
diazolidinylurea
imidazolidinyl urea

ASJC Scopus subject areas

  • Dermatology

Cite this

Sensitivity of petrolatum and aqueous vehicles for detecting allergy to imidazolidinylurea, diazolidinylurea, and DMDM hydantoin : A retrospective analysis from the North American contact dermatitis group. / Rietschel, Robert L.; Warshaw, Erin M.; Sasseville, Denis; Fowler, Joseph F.; DeLeo, Vincent A.; Belsito, Donald V.; Taylor, James S.; Storrs, Frances; Mathias, C. G Toby; Maibach, Howard I.; Marks, James G.; Zug, Kathryn A.; Pratt, Melanie.

In: Dermatitis, Vol. 18, No. 3, 09.2007, p. 155-162.

Research output: Contribution to journalArticle

Rietschel, RL, Warshaw, EM, Sasseville, D, Fowler, JF, DeLeo, VA, Belsito, DV, Taylor, JS, Storrs, F, Mathias, CGT, Maibach, HI, Marks, JG, Zug, KA & Pratt, M 2007, 'Sensitivity of petrolatum and aqueous vehicles for detecting allergy to imidazolidinylurea, diazolidinylurea, and DMDM hydantoin: A retrospective analysis from the North American contact dermatitis group', Dermatitis, vol. 18, no. 3, pp. 155-162. https://doi.org/10.2310/6620.2007.06040
Rietschel, Robert L. ; Warshaw, Erin M. ; Sasseville, Denis ; Fowler, Joseph F. ; DeLeo, Vincent A. ; Belsito, Donald V. ; Taylor, James S. ; Storrs, Frances ; Mathias, C. G Toby ; Maibach, Howard I. ; Marks, James G. ; Zug, Kathryn A. ; Pratt, Melanie. / Sensitivity of petrolatum and aqueous vehicles for detecting allergy to imidazolidinylurea, diazolidinylurea, and DMDM hydantoin : A retrospective analysis from the North American contact dermatitis group. In: Dermatitis. 2007 ; Vol. 18, No. 3. pp. 155-162.
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abstract = "Objective: To determine whether petrolatum or aqueous vehicles are more sensitive for detecting allergy to imidazolidinylurea (IU), diazolidinylurea (DU), and dimethylol dimethyl hydantoin (DM). The relationship of these allergens to formaldehyde sensitivity was also explored. Methods: Retrospective analysis of patients patch-tested by the North American Contact Dermatitis Group. All patients were simultaneously tested to seven allergens (formaldehyde, IU in petrolatum [pet], IU aqueous [aq], DU pet, DU aq, DM pet, and DM aq). Data were analyzed in pairs with various {"}gold standard{"} definitions of {"}true allergy{"} and adjusting for correlated data. Results: Reaction to at least one of the seven allergens occurred in 2,398 patients. In all cases except one (which just approached statistical significance), the petrolatum-based allergen was statistically significantly more sensitive than the same allergen in an aqueous base. Most of the patients allergic to the three preservatives were also allergic to formaldehyde, but most formaldehyde- allergic patients were not allergic to the IU, DU, or DM. Conclusion: Of these two vehicles, petrolatum is significantly more sensitive than an aqueous vehicle is for detecting allergy to IU, DU, and DM.",
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AU - Rietschel, Robert L.

AU - Warshaw, Erin M.

AU - Sasseville, Denis

AU - Fowler, Joseph F.

AU - DeLeo, Vincent A.

AU - Belsito, Donald V.

AU - Taylor, James S.

AU - Storrs, Frances

AU - Mathias, C. G Toby

AU - Maibach, Howard I.

AU - Marks, James G.

AU - Zug, Kathryn A.

AU - Pratt, Melanie

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N2 - Objective: To determine whether petrolatum or aqueous vehicles are more sensitive for detecting allergy to imidazolidinylurea (IU), diazolidinylurea (DU), and dimethylol dimethyl hydantoin (DM). The relationship of these allergens to formaldehyde sensitivity was also explored. Methods: Retrospective analysis of patients patch-tested by the North American Contact Dermatitis Group. All patients were simultaneously tested to seven allergens (formaldehyde, IU in petrolatum [pet], IU aqueous [aq], DU pet, DU aq, DM pet, and DM aq). Data were analyzed in pairs with various "gold standard" definitions of "true allergy" and adjusting for correlated data. Results: Reaction to at least one of the seven allergens occurred in 2,398 patients. In all cases except one (which just approached statistical significance), the petrolatum-based allergen was statistically significantly more sensitive than the same allergen in an aqueous base. Most of the patients allergic to the three preservatives were also allergic to formaldehyde, but most formaldehyde- allergic patients were not allergic to the IU, DU, or DM. Conclusion: Of these two vehicles, petrolatum is significantly more sensitive than an aqueous vehicle is for detecting allergy to IU, DU, and DM.

AB - Objective: To determine whether petrolatum or aqueous vehicles are more sensitive for detecting allergy to imidazolidinylurea (IU), diazolidinylurea (DU), and dimethylol dimethyl hydantoin (DM). The relationship of these allergens to formaldehyde sensitivity was also explored. Methods: Retrospective analysis of patients patch-tested by the North American Contact Dermatitis Group. All patients were simultaneously tested to seven allergens (formaldehyde, IU in petrolatum [pet], IU aqueous [aq], DU pet, DU aq, DM pet, and DM aq). Data were analyzed in pairs with various "gold standard" definitions of "true allergy" and adjusting for correlated data. Results: Reaction to at least one of the seven allergens occurred in 2,398 patients. In all cases except one (which just approached statistical significance), the petrolatum-based allergen was statistically significantly more sensitive than the same allergen in an aqueous base. Most of the patients allergic to the three preservatives were also allergic to formaldehyde, but most formaldehyde- allergic patients were not allergic to the IU, DU, or DM. Conclusion: Of these two vehicles, petrolatum is significantly more sensitive than an aqueous vehicle is for detecting allergy to IU, DU, and DM.

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