Sensitivity of fluid detection in patients with neovascular AMD using spectral domain optical coherence tomography high-definition line scans

Jennifer E. De Niro, H. Richard McDonald, Robert N. Johnson, J. Michael Jumper, Arthur D. Fu, Emmett T. Cunningham, Brandon Lujan

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

PURPOSE:: To determine the sensitivity of the Cirrus high-definition (HD) 5-line raster scans for detecting retinal fluid in neovascular age-related macular degeneration when using the spectral domain optical coherence tomography macular cubes as a gold standard. METHODS:: Patients were retrospectively identified from their initial follow-up visit after being newly diagnosed with neovascular age-related macular degeneration in at least one eye. Patients were imaged with Cirrus spectral domain optical coherence tomography using the 512 × 128 macular cube scan and HD 5-line raster scan settings. Patients with other diseases that cause subretinal or intraretinal fluid, or who had an epiretinal membrane causing macular traction were excluded from the analysis. We recorded the presence or absence of subretinal or intraretinal fluid in the macular cube and on the HD 5-line raster scans. RESULTS:: Seventy-nine patients met the study requirements. Of the 63 patients who had fluid present on the macular cube, 1 did not seem to have fluid on the HD 5-line raster scans. Taking the macular cube as a gold standard, the sensitivity of the HD 5-line raster scans for detecting retinal fluid in this cohort was 98.4%. CONCLUSION:: The Cirrus HD 5-line raster scans have a high sensitivity for detecting fluid in the macular cube in patients with neovascular age-related macular degeneration.

Original languageEnglish (US)
Pages (from-to)1163-1166
Number of pages4
JournalRetina
Volume34
Issue number6
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Optical Coherence Tomography
Macular Degeneration
Epiretinal Membrane
Traction

Keywords

  • Cirrus
  • Intraretinal fluid
  • Macular cube
  • Neovascular age-related macular degeneration
  • Sensitivity
  • Subretinal fluid

ASJC Scopus subject areas

  • Ophthalmology
  • Medicine(all)

Cite this

Sensitivity of fluid detection in patients with neovascular AMD using spectral domain optical coherence tomography high-definition line scans. / De Niro, Jennifer E.; McDonald, H. Richard; Johnson, Robert N.; Jumper, J. Michael; Fu, Arthur D.; Cunningham, Emmett T.; Lujan, Brandon.

In: Retina, Vol. 34, No. 6, 2014, p. 1163-1166.

Research output: Contribution to journalArticle

De Niro, Jennifer E. ; McDonald, H. Richard ; Johnson, Robert N. ; Jumper, J. Michael ; Fu, Arthur D. ; Cunningham, Emmett T. ; Lujan, Brandon. / Sensitivity of fluid detection in patients with neovascular AMD using spectral domain optical coherence tomography high-definition line scans. In: Retina. 2014 ; Vol. 34, No. 6. pp. 1163-1166.
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AB - PURPOSE:: To determine the sensitivity of the Cirrus high-definition (HD) 5-line raster scans for detecting retinal fluid in neovascular age-related macular degeneration when using the spectral domain optical coherence tomography macular cubes as a gold standard. METHODS:: Patients were retrospectively identified from their initial follow-up visit after being newly diagnosed with neovascular age-related macular degeneration in at least one eye. Patients were imaged with Cirrus spectral domain optical coherence tomography using the 512 × 128 macular cube scan and HD 5-line raster scan settings. Patients with other diseases that cause subretinal or intraretinal fluid, or who had an epiretinal membrane causing macular traction were excluded from the analysis. We recorded the presence or absence of subretinal or intraretinal fluid in the macular cube and on the HD 5-line raster scans. RESULTS:: Seventy-nine patients met the study requirements. Of the 63 patients who had fluid present on the macular cube, 1 did not seem to have fluid on the HD 5-line raster scans. Taking the macular cube as a gold standard, the sensitivity of the HD 5-line raster scans for detecting retinal fluid in this cohort was 98.4%. CONCLUSION:: The Cirrus HD 5-line raster scans have a high sensitivity for detecting fluid in the macular cube in patients with neovascular age-related macular degeneration.

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