Semisynthesis of a functional K+ channel

Francis Valiyaveetil, Matthew Sekedat, Tom W. Muir, Roderick MacKinnon

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Selective ion-conduction properties in lipid membranes have been found for a semisynthetic KcsA K+ channel containing a mutation (A98G) that allows the channel to open. Thus, it is now possible to study ion conduction in a K+ channel with chemical modification of the main-chain atoms of the selectivity filter. The picture shows the single-channel responses of the semisynthetic K+ channel and its structure.

Original languageEnglish (US)
Pages (from-to)2504-2507
Number of pages4
JournalAngewandte Chemie - International Edition
Volume43
Issue number19
DOIs
StatePublished - May 3 2004
Externally publishedYes

Fingerprint

Ions
Chemical modification
Membrane Lipids
Atoms

Keywords

  • Ion channels
  • Peptides
  • Potassium
  • Protein engineering

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Semisynthesis of a functional K+ channel. / Valiyaveetil, Francis; Sekedat, Matthew; Muir, Tom W.; MacKinnon, Roderick.

In: Angewandte Chemie - International Edition, Vol. 43, No. 19, 03.05.2004, p. 2504-2507.

Research output: Contribution to journalArticle

Valiyaveetil, Francis ; Sekedat, Matthew ; Muir, Tom W. ; MacKinnon, Roderick. / Semisynthesis of a functional K+ channel. In: Angewandte Chemie - International Edition. 2004 ; Vol. 43, No. 19. pp. 2504-2507.
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